Salgado C, Feliu E, Montserrat E, Villamor N, Ordi J, Aguilar J L, Vives-Corrons J L, Rozman C
Biological Hematology Department, Postgraduate School of Hematology, Farreras Valenti, Hospital Clinic, Barcelona, Spain.
Acta Haematol. 1993;89(1):46-9. doi: 10.1159/000204483.
A B-type large-cell primary splenic lymphoma with massive red-pulp involvement was diagnosed in a 64-year-old woman presenting with malaise, fever, anemia, atypical lymphoid cells in peripheral blood, and splenomegaly. This case differs from most splenic lymphomas both macroscopically and microscopically. At macroscopic examination, the spleen was homogeneously red without tumoral nodules or masses. Microscopically, the cords of the red pulp were extensively invaded by tumor cells maintaining patient sinuses. The white pulp was reduced by expansion of the red pulp. To our knowledge only few additional cases of splenic lymphoma with similar features have been previously described. The differential diagnosis of this unusual form of lymphoma with other lymphoproliferative disorders is briefly discussed.
一名64岁女性被诊断为B型大细胞原发性脾淋巴瘤，伴有大量红髓受累，患者表现为不适、发热、贫血、外周血中出现非典型淋巴细胞以及脾肿大。该病例在宏观和微观上均与大多数脾淋巴瘤不同。在宏观检查中，脾脏呈均匀红色，无肿瘤结节或肿块。微观上，红髓索被维持脾窦的肿瘤细胞广泛侵袭。白髓因红髓扩张而减少。据我们所知，此前仅另有少数具有类似特征的脾淋巴瘤病例被描述过。本文简要讨论了这种不寻常形式的淋巴瘤与其他淋巴增殖性疾病的鉴别诊断。
