McGarvey S T, Wu G, Zhang S, Wang Y, Peters P, Olds G R, Wiest P M
Department of Medicine, Miriam Hospital, Providence, Rhode Island.
Am J Trop Med Hyg. 1993 Apr;48(4):547-53. doi: 10.4269/ajtmh.1993.48.547.
The association between schistosomiasis japonica and nutritional status and child growth was studied cross-sectionally in 239 males and females (age range 4-19.9 years) residing in Jishan Island in Po Yang Lake in an endemic region of Jiangxi, China. The presence of Schistosoma japonicum eggs in Kato stool smears and the intensity of schistosomiasis as assessed by quantitative egg count were determined, as were the presence of hookworm, Ascaris, and Trichuris eggs. Anthropometric measures included stature, weight, weight-for-height, upper arm muscle area, and the sum of triceps and subscapular skinfold thickness. The association between schistosomiasis and nutritional status and growth was analyzed with multivariable models adjusted for the influence of age, age2, and polyparasitism. The prevalence of schistosomiasis was approximately 70% in both males and females. Current schistosomiasis and its intensity were significantly related to reduced stature, weight, weight-for-height, and the sum of skinfolds (all P < 0.01) in females across the entire age-span. The greatest age-specific differences were during adolescence in females: 4 cm in height and 5 kg in weight. In males, intensity of schistosomiasis was related (P < 0.03) only to the sum of skinfolds. The cross-sectional associations between anthropometric reductions and schistosomiasis japonica in childhood and adolescence indicate a strong independent effect of infection on malnutrition and growth in this population from a highly endemic region of China.
在中国江西一个血吸虫病流行区的鄱阳湖中矶山岛，对239名男性和女性（年龄范围4 - 19.9岁）进行了血吸虫病与营养状况及儿童生长之间关联的横断面研究。通过加藤粪便涂片确定日本血吸虫卵的存在情况，并通过定量虫卵计数评估血吸虫病的严重程度，同时也检测钩虫、蛔虫和鞭虫卵的存在情况。人体测量指标包括身高、体重、身高别体重、上臂肌肉面积以及肱三头肌和肩胛下皮褶厚度之和。采用多变量模型分析血吸虫病与营养状况及生长之间的关联，并对年龄、年龄平方和多重寄生虫感染的影响进行了校正。男性和女性的血吸虫病患病率均约为70%。在整个年龄跨度的女性中，当前的血吸虫病及其严重程度与身高、体重、身高别体重以及皮褶厚度之和的降低显著相关（所有P < 0.01）。女性青春期的年龄特异性差异最大：身高降低4厘米，体重降低5千克。在男性中，血吸虫病严重程度仅与皮褶厚度之和相关（P < 0.03）。儿童期和青春期人体测量指标降低与日本血吸虫病之间的横断面关联表明，在这个来自中国高度流行区的人群中，感染对营养不良和生长具有强烈的独立影响。
