Gazelle G S, Haaga J R, Rowland D Y
Department of Radiology, Case Western Reserve University, Cleveland, Ohio.
J Vasc Interv Radiol. 1993 Mar-Apr;4(2):305-10. doi: 10.1016/s1051-0443(93)71865-5.
This study was undertaken to address the effect of platelet dysfunction on bleeding associated with percutaneous needle biopsy.
With use of an established animal model, 199 biopsies were performed on the livers of 13 anesthetized pigs (95 on control animals, 104 on venopirin-treated animals). The needles used were 16-22-gauge Chiba type, 18-gauge Tru-Cut, and 18-gauge Menghini. The biopsies were performed under direct vision at laparotomy with consistent technique. Blood loss was measured, and the results were compared. Statistical analysis was performed with the Student t test and the Turkey test, after logarithmic transformation of the data.
A substantial increase in blood loss resulting from the biopsy procedures was demonstrated in the animals with platelet dysfunction. This was much greater than the effect of either needle size or prothrombin time prolongation previously reported by the authors.
Platelet function may be an important factor in determining the risk of bleeding due to percutaneous needle biopsy.
本研究旨在探讨血小板功能障碍对经皮穿刺活检相关出血的影响。
使用已建立的动物模型，对13只麻醉猪的肝脏进行了199次活检（95次针对对照动物，104次针对维诺匹林治疗的动物）。使用的针为16 - 22号千叶型、18号Tru - Cut和18号Menghini针。活检在剖腹手术直视下采用一致的技术进行。测量失血量并比较结果。在对数据进行对数转换后，采用学生t检验和Turkey检验进行统计分析。
血小板功能障碍的动物中，活检操作导致的失血量显著增加。这比作者先前报道的针尺寸或凝血酶原时间延长的影响要大得多。
血小板功能可能是决定经皮穿刺活检出血风险的一个重要因素。
