狼疮自身抗体的致病意义及诊断价值
Pathogenic significance and diagnostic value of lupus autoantibodies.
作者信息
Tomer Y, Buskila D, Shoenfeld Y
机构信息
Department of Medicine B, Sheba Medical Center, Tel-Hashomer, Israel.
出版信息
Int Arch Allergy Immunol. 1993;100(4):293-306. doi: 10.1159/000236429.
Systemic lupus erythematosus (SLE) is characterized by a panoply of autoantibodies (more than 50). Some of them are more prevalent (anti-ds DNA > 80%) while others are less frequently detected, but highly specific for SLE (anti-Sm, 20%). In this review we will discuss the clinical significance of anti-RNP, anti-Ro, anti-La and anti-phospholipid antibodies. We will also summarize the clinical and experimental evidence for the pathogenic role attributed to each one of these antibodies.
系统性红斑狼疮（SLE）的特征是存在大量自身抗体（超过50种）。其中一些更为常见（抗双链DNA抗体>80%），而其他一些则较少被检测到，但对SLE具有高度特异性（抗Sm抗体，20%）。在本综述中，我们将讨论抗RNP抗体、抗Ro抗体、抗La抗体和抗磷脂抗体的临床意义。我们还将总结归因于这些抗体中每一种的致病作用的临床和实验证据。
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