Lai L C, Cornell C, Lennard T W
Department of Clinical Biochemistry, Freeman Hospital, Newcastle upon Tyne, UK.
Cancer Lett. 1993 Apr 15;69(1):21-5. doi: 10.1016/0304-3835(93)90027-7.
Women who have breast cysts with intracystic Na+/K+ < 3 may have a higher risk of developing breast cancer than women who have breast cysts with intracystic Na+/K+ > 3. In this study wide-ranging intracystic concentrations of cathepsin D and pS2 (oestrogen inducible proteins/polypeptides) as well as oestradiol were found. The concentrations of cathepsin D and oestradiol were significantly higher in the low electrolyte ratio cyst group than in the high electrolyte ratio cyst group. No significant difference was found between pS2 concentrations in the two groups. The significantly higher intracystic concentrations of cathepsin D, a mitogenic lysosomal endopeptidase and oestradiol in the low electrolyte ratio group may partly provide an explanation for the higher risk of breast cancer which has been observed in this group of women.
囊内钠钾比小于3的乳腺囊肿女性比囊内钠钾比大于3的乳腺囊肿女性患乳腺癌的风险可能更高。在本研究中，发现了组织蛋白酶D和pS2（雌激素诱导蛋白/多肽）以及雌二醇在囊内的广泛浓度。低电解质比囊肿组中组织蛋白酶D和雌二醇的浓度显著高于高电解质比囊肿组。两组间pS2浓度未发现显著差异。低电解质比组中作为促有丝分裂溶酶体肽链内切酶的组织蛋白酶D和雌二醇在囊内的显著更高浓度可能部分解释了在这组女性中观察到的较高乳腺癌风险。
