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[结直肠癌肝转移灶的切除。结果与预后因素]

[Resection of liver metastases of colorectal cancers. Results and prognostic factors].

作者信息

Henne-Bruns D, Vogel I, Schröder S, Schreiber H W, Kremer B

机构信息

Klinik für Allgemeine Chirurgie und Thoraxchirurgie, Christian-Albrechts-Universität Kiel.

出版信息

Chirurg. 1993 Apr;64(4):283-7; discussion 288-9.

PMID:8482144
Abstract

Between 1985 and 1991 268 liver resections were performed at the Department of Surgery of the University of Hamburg. 89 patients underwent liver resections because of colo-rectal secondaries. 82 patients could be followed for more than 1 year postoperatively. Their courses were analysed regarding the prognostic factors: age, sex, localisation of the primary tumor, size, number and localisation of metastases and radicality (R0-R1-R2-stage of resection). The results showed, that a significant prognostic influence regarding the long-term-survival rate could only be observed in patients, in which a R0-resection with a tumor-free margin of more than 1 cm was performed. In these patients the cumulative 5-year survival rate was 37% with a median survival time of 39 months. In patients with a tumor-free margin < 1 cm (R0b) the long-term prognosis did not differ significantly from cases with R1 or R2 resections (under 10%).

摘要

1985年至1991年间,汉堡大学外科进行了268例肝脏切除术。89例患者因结直肠癌肝转移接受肝脏切除术。82例患者术后随访超过1年。分析了他们的病程与预后因素的关系:年龄、性别、原发肿瘤部位、大小、转移灶数量和部位以及根治性(切除的R0 - R1 - R2分期)。结果显示,只有那些切缘无肿瘤且切缘宽度超过1 cm的R0切除患者,长期生存率才受到显著的预后影响。这些患者的累积5年生存率为37%,中位生存时间为39个月。切缘无肿瘤但宽度<1 cm(R0b)的患者,其长期预后与R1或R2切除的患者相比无显著差异(低于10%)。

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