al-Dhohayan A, al-Sebayl M, Shibl A, al-Eshalwy S, Kattan K, al-Saleh M
Department of Surgery, King Saud University, Riyadh, Saudi Arabia.
Eur Surg Res. 1993 Jan-Feb;25(1):60-4. doi: 10.1159/000129258.
Augmentin as single agent was compared to the combination of metronidazole/gentamicin in the prevention of sepsis after appendicectomy. Two hundred patients admitted to Riyadh Central Hospital with a clinical diagnosis of acute appendicitis were enrolled in a prospective randomized study. All patients had a preoperative chest X ray, CBC, urinalysis and any other necessary investigations. Patients received either drug regime intravenously, 30 min prior to surgery. The overall incidence of wound infections in the Augmentin group was 8% as compared to 14% in the metronidazole/gentamicin group. There were no intra-abdominal abscesses in either group. Patients with perforated or gangrenous appendices received a 3- to 5-day course of treatment. All the early wound infection (2-4 days after operation) occurred in patients with gangrenous or perforated appendices. The results were studied statistically using chi 2 and there was no statistically significant difference between the infection rates in the two treatment groups whatever the state of the appendix at operation. Augmentin is as effective and well-tolerated as metronidazole/gentamicin in the prevention of wound infection following appendicectomy. The ease of administration of one drug with added anti-anaerobic property makes Augmentin superior to the tested combination.
在阑尾切除术后预防败血症方面，将阿莫西林作为单一药物与甲硝唑/庆大霉素联合用药进行了比较。对利雅得中央医院收治的200例临床诊断为急性阑尾炎的患者进行了一项前瞻性随机研究。所有患者术前均进行了胸部X光检查、血常规、尿液分析及其他必要检查。患者在手术前30分钟静脉接受其中一种药物治疗方案。阿莫西林组伤口感染的总体发生率为8%，而甲硝唑/庆大霉素组为14%。两组均未出现腹腔内脓肿。患有穿孔性或坏疽性阑尾炎的患者接受3至5天的疗程治疗。所有早期伤口感染（术后2至4天）均发生在患有坏疽性或穿孔性阑尾炎的患者中。使用卡方检验对结果进行统计学研究，无论手术时阑尾的状态如何，两个治疗组的感染率之间均无统计学显著差异。在阑尾切除术后预防伤口感染方面，阿莫西林与甲硝唑/庆大霉素一样有效且耐受性良好。单一药物给药简便且具有额外的抗厌氧特性，使得阿莫西林优于所测试的联合用药。
