Suppr超能文献

小儿阑尾炎的细菌谱及抗生素选择:一项回顾性队列研究。

Bacterial profile and antibiotic selection for pediatric appendicitis: A retrospective cohort study.

作者信息

Naji Hussein, Jayakumar Joanna, Ali Rola

机构信息

Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.

Mediclinic Parkview Hospital, Dubai, United Arab Emirates.

出版信息

Surg Open Sci. 2023 Jul 27;14:120-123. doi: 10.1016/j.sopen.2023.07.018. eCollection 2023 Aug.

Abstract

OBJECTIVE

The objective of this study was to identify the predominant bacteria cultured from the surface of removed appendices in pediatric patients with acute appendicitis and determine the appropriate choice of antibiotics for preoperative and postoperative management.

METHODS

A 2-year retrospective cohort study was conducted at Mediclinic Parkview Hospital, Dubai, UAE. Patients under 14 years of age with diagnosed acute appendicitis who underwent laparoscopic appendectomy were included. Swab cultures, along with demographic, laboratory, and pathology data, were analyzed.

RESULTS

Out of the 56 enrolled patients, 27 (48 %) exhibited bacterial growth on swab cultures, while 29 (52 %) showed no bacterial growth. () was the predominant isolated bacteria, present in 23/27 patients (85 %). Seven patients had co-infections involving and other bacteria, with Pseudomonas being the second most common bacteria identified in 7/27 patients (25 %). Antibiotic sensitivity testing indicated that 85 % of the isolated bacteria were sensitive to Gentamicin, 63 % to Amoxicillin/Clavulanic acid, 59 % to Trimethoprim + Sulfamethoxazole, and 27 % to Cefazolin.

CONCLUSION

was the most prevalent bacteria identified on swabs taken from inflamed appendices in pediatric patients. Amoxicillin/Clavulanic acid was determined to be an appropriate choice for preoperative prophylaxis. This study provides valuable insights for guiding the management of pediatric appendicitis and facilitating the appropriate and judicious use of antibiotics.

摘要

目的

本研究的目的是确定急性阑尾炎患儿切除阑尾表面培养出的主要细菌,并确定术前和术后管理中抗生素的合适选择。

方法

在阿联酋迪拜的 Mediclinic Parkview 医院进行了一项为期 2 年的回顾性队列研究。纳入 14 岁以下诊断为急性阑尾炎并接受腹腔镜阑尾切除术的患者。对拭子培养物以及人口统计学、实验室和病理学数据进行分析。

结果

在 56 名登记患者中,27 名(48%)拭子培养物显示有细菌生长,而 29 名(52%)未显示细菌生长。(此处原文括号内容缺失)是主要分离出的细菌,存在于 23/27 名患者(85%)中。7 名患者有合并感染,涉及(此处原文缺失)和其他细菌,铜绿假单胞菌是在 7/27 名患者(25%)中鉴定出的第二常见细菌。抗生素敏感性测试表明,85%的分离细菌对庆大霉素敏感,63%对阿莫西林/克拉维酸敏感,59%对甲氧苄啶 + 磺胺甲恶唑敏感,27%对头孢唑林敏感。

结论

(此处原文缺失)是在儿科患者发炎阑尾拭子上鉴定出的最普遍细菌。阿莫西林/克拉维酸被确定为术前预防的合适选择。本研究为指导小儿阑尾炎的管理和促进抗生素的合理明智使用提供了有价值的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab52/10404798/0bd911950908/gr1.jpg

相似文献

1
Bacterial profile and antibiotic selection for pediatric appendicitis: A retrospective cohort study.
Surg Open Sci. 2023 Jul 27;14:120-123. doi: 10.1016/j.sopen.2023.07.018. eCollection 2023 Aug.
4
Microbiota Assessment of Pediatric Simple and Complex Acute Appendicitis.
Medicina (Kaunas). 2022 Aug 23;58(9):1144. doi: 10.3390/medicina58091144.
5
Uselessness of microbiological samples in acute appendicitis with frank pus: to collect or not to collect?
Eur J Trauma Emerg Surg. 2020 Aug;46(4):835-839. doi: 10.1007/s00068-018-1031-7. Epub 2018 Oct 12.
6
Bacteriology of acute appendicitis and its implication for the use of prophylactic antibiotics.
Surg Infect (Larchmt). 2012 Dec;13(6):383-90. doi: 10.1089/sur.2011.135. Epub 2012 Dec 11.
7
Evidence-based optimisation of empirical antibiotic regimens in paediatric complicated appendicitis: a retrospective study of 94 patients.
Swiss Med Wkly. 2022 Sep 6;152:w30222. doi: 10.4414/smw.2022.w30222. eCollection 2022 Aug 29.
8
Optimal First-Line Antibiotic Treatment for Pediatric Complicated Appendicitis Based on Peritoneal Fluid Culture.
Pediatr Gastroenterol Hepatol Nutr. 2021 Nov;24(6):510-517. doi: 10.5223/pghn.2021.24.6.510. Epub 2021 Nov 5.
9
The microbiology of bacterial peritonitis due to appendicitis in children.
Ir J Med Sci. 2014 Dec;183(4):585-91. doi: 10.1007/s11845-013-1055-2. Epub 2013 Dec 18.
10
Bacterial pathogens in pediatric appendicitis: a comprehensive retrospective study.
Front Cell Infect Microbiol. 2023 May 9;13:1027769. doi: 10.3389/fcimb.2023.1027769. eCollection 2023.

引用本文的文献

本文引用的文献

1
Antibiotics vs. Appendectomy for Acute Uncomplicated Appendicitis in Adults: Review of the Evidence and Future Directions.
Surg Infect (Larchmt). 2017 Jul;18(5):527-535. doi: 10.1089/sur.2017.073. Epub 2017 Jun 14.
2
The Global Incidence of Appendicitis: A Systematic Review of Population-based Studies.
Ann Surg. 2017 Aug;266(2):237-241. doi: 10.1097/SLA.0000000000002188.
4
Clinical practice guidelines for antimicrobial prophylaxis in surgery.
Am J Health Syst Pharm. 2013 Feb 1;70(3):195-283. doi: 10.2146/ajhp120568.
6
Appendectomy versus antibiotic treatment for acute appendicitis.
Cochrane Database Syst Rev. 2011 Nov 9(11):CD008359. doi: 10.1002/14651858.CD008359.pub2.
8
Antibiotics versus placebo for prevention of postoperative infection after appendicectomy.
Cochrane Database Syst Rev. 2003(2):CD001439. doi: 10.1002/14651858.CD001439.
9
Appropriate prescribing of oral beta-lactam antibiotics.
Am Fam Physician. 2000 Aug 1;62(3):611-20.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验