单克隆抗生物素蛋白抗体在识别生物素方面模拟抗生物素蛋白。
Monoclonal anti-biotin antibodies simulate avidin in the recognition of biotin.
作者信息
Bagçi H, Kohen F, Kusçuoglu U, Bayer E A, Wilchek M
机构信息
Department of Hormone Research, Weizmann Institute of Science, Rehovot, Israel.
出版信息
FEBS Lett. 1993 May 3;322(1):47-50. doi: 10.1016/0014-5793(93)81108-c.
PMID:8482366
Abstract
The sequence of the VH gene of a monoclonal anti-biotin antibody was determined. Biotin-binding motifs, similar to those in avidin and streptavidin, were identified in complementary determining regions 2 and 3, suggesting that natural selection of functional motifs may occur in unrelated protein types.
摘要
测定了一种单克隆抗生物素蛋白抗体的VH基因序列。在互补决定区2和3中鉴定出与抗生物素蛋白和链霉抗生物素蛋白中相似的生物素结合基序，这表明功能性基序的自然选择可能发生在不相关的蛋白质类型中。
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