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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Gonzalez R A, Campos E O, Karmelic C, Moran S, Inestrosa N C

Department of Cardiology and Cardiovascular Diseases, Faculty of Medicine, Catholic University of Chile, Santiago.

Gen Pharmacol. 1993 Jan;24(1):111-4. doi: 10.1016/0306-3623(93)90019-t.

Clinical and experimental evidence suggest that changes in the autonomic tone play a role in the pathogenesis of atrial fibrillation. 2. We have studied the distribution of molecular forms of acetylcholinesterase (AChE) in atrial biopsies obtained from individuals without arrhythmias and in patients with atrial fibrillation. 3. Analysis of the distribution of globular and asymmetric AChE forms, showed a decrease in the amount of the globular forms of biopsies taken from atria during fibrillation. 4. This study is the first attempt to characterize the molecular forms of AChE in the human heart of patients with sinus rhythm and chronic atrial fibrillation.

临床和实验证据表明，自主神经张力的变化在房颤的发病机制中起作用。2. 我们研究了从无心律失常的个体以及房颤患者获取的心房活检组织中乙酰胆碱酯酶（AChE）分子形式的分布。3. 对球状和不对称AChE形式分布的分析表明，房颤时取自心房的活检组织中球状形式的数量减少。4. 本研究首次尝试对窦性心律和慢性房颤患者心脏中的AChE分子形式进行表征。

Gonzalez R A, Campos E O, Karmelic C, Moran S, Inestrosa N C

Department of Cardiology and Cardiovascular Diseases, Faculty of Medicine, Catholic University of Chile, Santiago.

Gen Pharmacol. 1993 Jan;24(1):111-4. doi: 10.1016/0306-3623(93)90019-t.

Clinical and experimental evidence suggest that changes in the autonomic tone play a role in the pathogenesis of atrial fibrillation. 2. We have studied the distribution of molecular forms of acetylcholinesterase (AChE) in atrial biopsies obtained from individuals without arrhythmias and in patients with atrial fibrillation. 3. Analysis of the distribution of globular and asymmetric AChE forms, showed a decrease in the amount of the globular forms of biopsies taken from atria during fibrillation. 4. This study is the first attempt to characterize the molecular forms of AChE in the human heart of patients with sinus rhythm and chronic atrial fibrillation.

临床和实验证据表明，自主神经张力的变化在房颤的发病机制中起作用。2. 我们研究了从无心律失常的个体以及房颤患者获取的心房活检组织中乙酰胆碱酯酶（AChE）分子形式的分布。3. 对球状和不对称AChE形式分布的分析表明，房颤时取自心房的活检组织中球状形式的数量减少。4. 本研究首次尝试对窦性心律和慢性房颤患者心脏中的AChE分子形式进行表征。