口服钒化合物治疗对胰岛素依赖型糖尿病大鼠气管平滑肌反应性的影响。

The effect of oral vanadyl treatment on the reactivity of tracheal smooth muscle obtained from insulin-dependent diabetic rats.

Ozansoy G, Karasu C, Ozçelikay A T

University of Ankara, Faculty of Pharmacy, Department of Pharmacology, Turkey.

Gen Pharmacol. 1993 Jan;24(1):115-9. doi: 10.1016/0306-3623(93)90020-x.

Abstract

In this study, we investigated the contractile effects of acetylcholine (ACh) and KCl in tracheas obtained from 12-13 wk insulin-dependent (ID)-diabetic rats. 2. The maximum contractile responses to ACh and KCl were significantly increased in ID-diabetic rat tracheas compared with those from controls. But the sensitivity (pD2 values) of ID-diabetic tracheas to these agents were not significantly altered relative to controls. 3. The alterations which occurred in ID-diabetic rats were prevented with oral vanadyl treatment during a 10 wk period.

摘要

在本研究中，我们调查了乙酰胆碱（ACh）和氯化钾（KCl）对取自12 - 13周龄胰岛素依赖型（ID）糖尿病大鼠气管的收缩作用。2. 与对照组相比，ID糖尿病大鼠气管对ACh和KCl的最大收缩反应显著增加。但ID糖尿病气管对这些药物的敏感性（pD2值）相对于对照组没有显著改变。3. 在10周期间口服钒酸盐治疗可预防ID糖尿病大鼠发生的这些改变。