Stosiek N, Peters K P, von den Driesch P
Universitäts Hautklinik Erlangen.
Hautarzt. 1993 Apr;44(4):235-7.
We report on a 40-year-old male patient who developed an unusual generalized drug eruption taking the form of a histologically confirmed pityriasis lichenoides et varioliformis acuta (PLEVA) after oral intake of the H1-antagonist astemizole. On two occasions, independently repeated medication with astemizole exacerbated the typical rash again. Oral exposure and the specific lymphocyte transformation test confirmed the suspected causal connection between astemizole and PLEVA.
我们报告了一名40岁男性患者，其在口服H1拮抗剂阿司咪唑后出现了一种不寻常的全身性药疹，组织学确诊为急性痘疮样苔藓样糠疹（PLEVA）。有两次，独立重复使用阿司咪唑再次加重了典型皮疹。口服暴露和特异性淋巴细胞转化试验证实了阿司咪唑与PLEVA之间疑似的因果关系。
