Mangoud A M, Emara M W, Ghobish A, Khalil O M, Mossad A, el Feky H M, el-Ashtokhy M, Hamdi K N, Morsy T A
Department of Pathology, Faculty of Medicine, Zagazig University, Egypt.
J Egypt Soc Parasitol. 1993 Apr;23(1):43-54.
Twenty biopsied material of the testicular tissue were obtained from patients with unilateral hydrocele (eight due to lymphatic filariasis and twelve of idiopathic causes). Twenty biopsies lymphatic were also obtained from the normal unaffected testes and were used as control. The data obtained from histopathological, histochemical and ultrastructural studies revealed alternation in the testicular tissue with hydrocele than in the normal control testis. In the filarial hydrocele 37.5% of the cases showed thickening of the basement membrane and fibrosis with arrest of the spermatogenesis at the level of secondary spermatocytes. In addition, 12.5% showed thickening with interstitial fibrosis. Microfilariae were seen in hydrocele fluid of 3/8 cases (37.5%). In the idiopathic hydrocele 50% of the testicular tissue showed marked collagen deposits and testicular atrophy with fibrosis and thickening of basement membrane. The second 50% of cases showed variable degree of maturation arrests. Explanation for these variations in the pathological and anatomical pictures in both types of hydrocele is suggested. In the filariasis hydrocele it is due to the inflammatory response that may subside and recurrent. In the idiopathic hydrocele, it is due to the irreversible hypoxia caused by the continuous mechanical pressure due to huge amount of hydrocele fluid resulting in irreversible degenerative process with marked fibrosis.
从单侧鞘膜积液患者身上获取了20份睾丸组织活检材料（其中8例由淋巴丝虫病引起，12例为特发性病因）。还从正常未受影响的睾丸获取了20份淋巴组织活检样本作为对照。组织病理学、组织化学和超微结构研究所得数据显示，与正常对照睾丸相比，鞘膜积液患者的睾丸组织出现了改变。在丝虫性鞘膜积液中，37.5%的病例显示基底膜增厚和纤维化，精子发生在次级精母细胞水平停滞。此外，12.5%显示基底膜增厚伴间质纤维化。在8例中的3例（37.5%）鞘膜积液液中发现了微丝蚴。在特发性鞘膜积液中，50%的睾丸组织显示明显的胶原沉积、睾丸萎缩伴纤维化和基底膜增厚。另外50%的病例显示不同程度的成熟停滞。文中对两种类型鞘膜积液的病理和解剖图像中的这些差异给出了解释。在丝虫性鞘膜积液中，这是由于炎症反应可能消退并复发。在特发性鞘膜积液中，这是由于大量鞘膜积液产生的持续机械压力导致不可逆的缺氧，从而引发伴有明显纤维化的不可逆退行性过程。
