McLean B N, Zeman A Z, Barnes D, Thompson E J
Department of Neurology, National Hospitals for Neurology and Neurosurgery, London.
J Neurol Neurosurg Psychiatry. 1993 Apr;56(4):356-60. doi: 10.1136/jnnp.56.4.356.
Seventy four patients with clinically definite multiple sclerosis were studied by using polyacrylamide gel electrophoresis of cerebrospinal fluid to assess blood-brain barrier function. Blood-brain barrier impairment was associated with recent clinical relapses of multiple sclerosis and worsened across a spectrum from the relapsing-remitting type of multiple sclerosis to secondary and primary progressive disease. The association between blood-brain barrier impairment and primary progressive disease is particularly interesting in the light of recent evidence that focal gadolinium enhancement on MRI is relatively unusual in patients with this disease.
通过使用脑脊液聚丙烯酰胺凝胶电泳来评估血脑屏障功能，对74例临床确诊的多发性硬化症患者进行了研究。血脑屏障损伤与多发性硬化症近期的临床复发相关，并且在从复发缓解型多发性硬化症到继发和原发进展型疾病的整个范围内都有所恶化。鉴于最近有证据表明，患有这种疾病的患者在MRI上出现局灶性钆增强相对不常见，血脑屏障损伤与原发进展型疾病之间的关联尤其令人感兴趣。
