Kennedy W R, Wendelschafer-Crabb G
Department of Neurology, University of Minnesota, Minneapolis.
J Neurol Sci. 1993 Apr;115(2):184-90. doi: 10.1016/0022-510x(93)90223-l.
Using immunohistochemical procedures numerous nerve fibers have been found in all cell layers of human epidermis. These nerves originate from nerve trunks in the dermis, enter the epidermis, then divide distally to eventually end in small enlargements, near the surface of the skin and in deeper areas. Some endings may be external to stratum granulosum cells. Epidermal nerves appear to have a three-dimensional territorial distribution in relationship to the skin's surface. The presence of epidermal nerve fibers was confirmed by electron microscope studies. The nerves are presumed to be sensory in nature. The existence of epidermal nerve fibers will necessitate changes in present theory of structure and function of peripheral sensation.
运用免疫组化方法，已在人类表皮的所有细胞层中发现了大量神经纤维。这些神经起源于真皮中的神经干，进入表皮，然后向远端分支，最终在皮肤表面附近和更深区域以小的膨大形式终止。一些末梢可能位于颗粒层细胞之外。表皮神经相对于皮肤表面似乎具有三维空间分布。电子显微镜研究证实了表皮神经纤维的存在。这些神经被认为本质上是感觉神经。表皮神经纤维的存在将需要对目前关于周围感觉的结构和功能理论进行修正。
