Mano Y, Nakamuro T, Takayanagi T, Mayer R F
Department of Neurology, Nara Medical University, Japan.
J Neurol. 1993;240(3):144-8. doi: 10.1007/BF00857518.
Two men, aged 63 and 71 years, developed a gross action tremor and dysesthesias several months after an intracerebral hemorrhage. CT and MRI showed a small hemorrhage in the posterior region of the lateral nucleus of the thalamus in each patient. The tremor occurred on movement, had frequencies of 2.5-4.5 Hz and the amplitude varied depending on the joint position of the limb. Ceruletide (a cholecystokinin analog) 0.8 micrograms/kg i.m. produced a marked reduction in the action tremor and improved motor function. This effect appeared 10-15 min after the injection, and lasted for up to 4 weeks. It is suggested that ceruletide may be of value in the treatment of action tremors following a thalamic lesion.
两名男性，年龄分别为63岁和71岁，在脑出血数月后出现明显的动作性震颤和感觉异常。CT和MRI显示，每位患者丘脑外侧核后部区域有小出血灶。震颤在运动时出现，频率为2.5 - 4.5赫兹，振幅根据肢体关节位置而变化。蛙皮素（一种胆囊收缩素类似物）0.8微克/千克肌肉注射可使动作性震颤明显减轻并改善运动功能。这种效果在注射后10 - 15分钟出现，持续长达4周。提示蛙皮素可能对治疗丘脑病变后的动作性震颤有价值。
