Hashimoto T, Yanagisawa N
Department of Medicine (Neurology), Shinshu University School of Medicine, Matsumoto, Japan.
J Neurol Sci. 1990 Dec;100(1-2):178-85. doi: 10.1016/0022-510x(90)90031-h.
We studied the effects of ceruletide, a cholecystokinin analogue, on choreic involuntary movement in several neurological diseases by clinical scoring and electromyography in 11 patients. Ceruletide brought about a brief reduction of choreic movement reaching its maximum within 60 min and another long-lasting improvement over several weeks by single administration. The levels of homovanillic acid in cerebrospinal fluid before treatment were significantly higher in cases with long-lasting improvement than those in cases without improvement. We suggest that ceruletide may reduce choreic movement for a long period through effects on the central dopamine system and speculate that such a long-term effect may be accounted for by the change in transmission after the second messengers in neurons.
我们通过对11例患者进行临床评分和肌电图检查，研究了胆囊收缩素类似物雨蛙肽对几种神经疾病中舞蹈样不自主运动的影响。单次给药后，雨蛙肽可使舞蹈样运动短暂减少，在60分钟内达到最大值，并在数周内产生另一种持久的改善。在持久改善的病例中，治疗前脑脊液中高香草酸水平显著高于未改善的病例。我们认为，雨蛙肽可能通过对中枢多巴胺系统的作用长期减少舞蹈样运动，并推测这种长期效应可能是由神经元中第二信使后传递的变化所导致的。
