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大鼠实验性臂丛神经重建后运动功能客观临床评估中的行为学评估方法

Behavioral evaluating methods in the objective clinical assessment of motor function after experimental brachial plexus reconstruction in the rat.

作者信息

Bertelli J A, Mira J C

机构信息

Laboratoire de Neurobiologie, Université René Descartes, Paris, France.

出版信息

J Neurosci Methods. 1993 Mar;46(3):203-8. doi: 10.1016/0165-0270(93)90068-3.

Abstract

Unfortunately, the results of brachial plexus surgery have not fulfilled expectations. Although the components of the rat brachial plexus are similar to those of the human plexus, experimental work in this field is limited. No functional test to assess experimental brachial plexus reconstruction has so far been published. We worked out a method of evaluating brachial plexus impairment in rats in the laboratory. It consists of a simple test in which a bowl of water is projected over the animal's head, eliciting grooming movements of the forepaws towards the head. This test is therefore called the 'grooming test'. A system of scoring the animals' performance is suggested. Rats were also submitted to walking tracks analysis, but this was of limited value in assessing brachial plexus impairment.

摘要

不幸的是,臂丛神经手术的结果并未达到预期。尽管大鼠臂丛神经的组成部分与人类臂丛神经相似,但该领域的实验工作有限。迄今为止,尚未发表评估实验性臂丛神经重建的功能测试。我们在实验室中研究出了一种评估大鼠臂丛神经损伤的方法。它包括一个简单的测试,即将一碗水投射到动物头部上方,引发前爪朝着头部的梳理动作。因此,这个测试被称为“梳理测试”。我们提出了一个对动物表现进行评分的系统。大鼠也接受了行走轨迹分析,但这在评估臂丛神经损伤方面价值有限。

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