MacKenzie E, Stewart E, Birnie G D
Beatson Institute for Cancer Research, CRC Beatson Laboratories, Wolfson Laboratory for Molecular Pathology, Bearsden, Glasgow, UK.
Leukemia. 1993 May;7(5):702-6.
Polymerase chain reaction amplification of reverse transcription products has demonstrated the presence of abl-bcr hybrid mRNAs in RNA from peripheral blood leucocytes of Philadelphia-chromosome-positive chronic myeloid leukaemia patients; such hybrid mRNAs can contain either of the alternative first exons of c-abl. A survey of 12 CMLs has shown that abl-bcr mRNAs occur in the leucocytes of some, but not all, patients, and that they are present both in chronic-phase and acute-phase leucocytes.
逆转录产物的聚合酶链反应扩增已证实在费城染色体阳性的慢性髓性白血病患者外周血白细胞的RNA中存在abl-bcr杂交mRNA；此类杂交mRNA可包含c-abl的任一可变第一外显子。对12例慢性髓性白血病患者的一项调查显示，abl-bcr mRNA存在于部分而非全部患者的白细胞中，且在慢性期和急性期白细胞中均有存在。
