Barona de Guzmán R, Martorell M A, Basterra J, Armengot M, Alvarez-Valdés R, Garin L
Department of Otolaryngology, General Hospital, Valencia Medical School, Spain.
Laryngoscope. 1993 May;103(5):538-40. doi: 10.1288/00005537-199305000-00011.
The prognosis for supraglottic squamous cell carcinomas is difficult to establish. A study of 19 histopathological parameters (14 from the primary tumor and 5 from the lymph node metastases) was undertaken in 51 supraglottic epidermoid carcinomas. All patients were subjected to supraglottic horizontal laryngectomy with bilateral functional neck dissection and postoperative radiotherapy. A discriminant analysis was performed to relate the different histopathological variables to 5-year survival. Capsule rupture and the number of metastatic lymph nodes were the only two parameters significantly related to survival (P < .01). Histopathology (in particular, lymph node metastases) proved more effective in predicting patient evolution than TNM staging.
声门上型鳞状细胞癌的预后难以确定。对51例声门上型表皮样癌患者进行了一项关于19个组织病理学参数（14个来自原发肿瘤，5个来自淋巴结转移灶）的研究。所有患者均接受了声门上水平喉切除术加双侧功能性颈清扫术及术后放疗。进行判别分析以将不同的组织病理学变量与5年生存率相关联。包膜破裂和转移淋巴结数量是仅有的两个与生存率显著相关的参数（P <.01）。组织病理学（尤其是淋巴结转移情况）在预测患者病情进展方面比TNM分期更有效。
