Janot F, Klijanienko J, Russo A, Mamet J P, de Braud F, El-Naggar A K, Pignon J P, Luboinski B, Cvitkovic E
Department of Head and Neck Surgery, Institut Gustave Roussy, Villejuif, France.
Br J Cancer. 1996 Feb;73(4):531-8. doi: 10.1038/bjc.1996.92.
The prognostic weight of histological and biological factors was compared with that of known clinical prognostic factors in a population of 108 consecutive previously untreated patients with head and neck squamous cell carcinoma. Parameters studied were: tumour vascularisation, mitotic index, histological differentiation, nuclear grade, keratinisation, desmoplasia, growth pattern, inflammation, tumour emboli in peripheral vessels, keratins 6, 13, 19 immunohistochemical expression, cytofluorometric ploidy and S-phase. In multivariate analysis (Cox), only age and nodal status had a significant impact on the overall survival, whereas T stage was the only significant factor associated with locoregional failure. The cumulative incidence of metastases was correlated not only with age, T and N stage, but also with histological differentiation. All the other histological and biological factors studied failed to provide further prognostic information. These findings may help to select patients with high metastatic risk.
在108例连续的未经治疗的头颈部鳞状细胞癌患者中，将组织学和生物学因素的预后权重与已知临床预后因素的预后权重进行了比较。研究的参数包括：肿瘤血管生成、有丝分裂指数、组织学分化、核分级、角化、促纤维增生、生长模式、炎症、外周血管中的肿瘤栓子、角蛋白6、13、19免疫组化表达、细胞荧光测定法的倍体和S期。在多变量分析（Cox）中，只有年龄和淋巴结状态对总生存期有显著影响，而T分期是与局部区域失败相关的唯一显著因素。转移的累积发生率不仅与年龄、T和N分期相关，还与组织学分化相关。所研究的所有其他组织学和生物学因素均未能提供进一步的预后信息。这些发现可能有助于选择具有高转移风险的患者。
