头颈部鳞状细胞癌临床病理参数的预后价值：一项前瞻性分析。
Prognostic value of clinicopathological parameters in head and neck squamous cell carcinoma: a prospective analysis.
作者信息
Janot F, Klijanienko J, Russo A, Mamet J P, de Braud F, El-Naggar A K, Pignon J P, Luboinski B, Cvitkovic E
机构信息
Department of Head and Neck Surgery, Institut Gustave Roussy, Villejuif, France.
出版信息
Br J Cancer. 1996 Feb;73(4):531-8. doi: 10.1038/bjc.1996.92.
Abstract
The prognostic weight of histological and biological factors was compared with that of known clinical prognostic factors in a population of 108 consecutive previously untreated patients with head and neck squamous cell carcinoma. Parameters studied were: tumour vascularisation, mitotic index, histological differentiation, nuclear grade, keratinisation, desmoplasia, growth pattern, inflammation, tumour emboli in peripheral vessels, keratins 6, 13, 19 immunohistochemical expression, cytofluorometric ploidy and S-phase. In multivariate analysis (Cox), only age and nodal status had a significant impact on the overall survival, whereas T stage was the only significant factor associated with locoregional failure. The cumulative incidence of metastases was correlated not only with age, T and N stage, but also with histological differentiation. All the other histological and biological factors studied failed to provide further prognostic information. These findings may help to select patients with high metastatic risk.
摘要
在108例连续的未经治疗的头颈部鳞状细胞癌患者中，将组织学和生物学因素的预后权重与已知临床预后因素的预后权重进行了比较。研究的参数包括：肿瘤血管生成、有丝分裂指数、组织学分化、核分级、角化、促纤维增生、生长模式、炎症、外周血管中的肿瘤栓子、角蛋白6、13、19免疫组化表达、细胞荧光测定法的倍体和S期。在多变量分析（Cox）中，只有年龄和淋巴结状态对总生存期有显著影响，而T分期是与局部区域失败相关的唯一显著因素。转移的累积发生率不仅与年龄、T和N分期相关，还与组织学分化相关。所研究的所有其他组织学和生物学因素均未能提供进一步的预后信息。这些发现可能有助于选择具有高转移风险的患者。
相似文献
1
Prognostic value of clinicopathological parameters in head and neck squamous cell carcinoma: a prospective analysis.头颈部鳞状细胞癌临床病理参数的预后价值：一项前瞻性分析。
Br J Cancer. 1996 Feb;73(4):531-8. doi: 10.1038/bjc.1996.92.
2
3
Prognostic value of circulating biomarker score in advanced-stage head and neck squamous cell carcinoma.循环生物标志物评分在晚期头颈部鳞状细胞癌中的预后价值。
Eur J Cancer. 2018 Mar;92:69-76. doi: 10.1016/j.ejca.2018.01.069. Epub 2018 Feb 8.
4
Prognostic factors in head and neck cancer: histologic grading, DNA ploidy, and nodal status.头颈癌的预后因素：组织学分级、DNA倍体和淋巴结状态。
Head Neck. 1991 Nov-Dec;13(6):477-87. doi: 10.1002/hed.2880130603.
5
Prognostic role of regenerating gene-I in patients with stage-IV head and neck squamous cell carcinoma.再生基因-I在IV期头颈部鳞状细胞癌患者中的预后作用。
Diagn Pathol. 2016 Aug 18;11(1):79. doi: 10.1186/s13000-016-0526-y.
6
Primary tumor volume is an important predictor of clinical outcomes among patients with locally advanced squamous cell cancer of the head and neck treated with definitive chemoradiotherapy.原发肿瘤体积是接受根治性放化疗的局部晚期头颈部鳞状细胞癌患者临床结局的重要预测因素。
Int J Radiat Oncol Biol Phys. 2012 Apr 1;82(5):1823-30. doi: 10.1016/j.ijrobp.2010.10.053. Epub 2011 May 5.
7
Prognostic significance of basaloid squamous cell carcinoma in head and neck cancer.头颈部癌中基底样鳞状细胞癌的预后意义。
JAMA Otolaryngol Head Neck Surg. 2013 Dec;139(12):1306-11. doi: 10.1001/jamaoto.2013.5308.
8
Prognostic value of maximum standardized uptake value measured by pretreatment 18F-FDG PET/CT in locally advanced head and neck squamous cell carcinoma.治疗前 18F-FDG PET/CT 最大标准化摄取值对局部晚期头颈部鳞状细胞癌的预后价值。
Clin Transl Oncol. 2017 Nov;19(11):1337-1349. doi: 10.1007/s12094-017-1674-6. Epub 2017 May 24.
9
Prognostic significance of disease-free interval in head and neck cutaneous squamous cell carcinoma with nodal metastases.颈部淋巴结转移的头颈部皮肤鳞状细胞癌无病间期的预后意义。
Head Neck. 2013 Aug;35(8):1138-43. doi: 10.1002/hed.23096. Epub 2012 Nov 14.
10
Prognostic relevance of insulin resistance on disease-free survival in head and neck squamous cell carcinomas: Preliminary results.胰岛素抵抗对头颈部鳞状细胞癌无病生存期的预后相关性：初步结果。
Head Neck. 2017 Dec;39(12):2501-2511. doi: 10.1002/hed.24919. Epub 2017 Sep 30.
引用本文的文献
1
Stage of presentation and survival rates of head and neck cancer in Western Cape, South Africa.南非西开普省头颈癌的就诊阶段和生存率
J Coll Med S Afr. 2024 Mar 15;2(1):2. doi: 10.4102/jcmsa.v2i1.2. eCollection 2024.
2
Decoding the basis of histological variation in human cancer.解析人类癌症组织学变异的基础。
Nat Rev Cancer. 2024 Feb;24(2):141-158. doi: 10.1038/s41568-023-00648-5. Epub 2023 Dec 22.
3
The utility of diffusion-weighted T2 mapping for the prediction of histological tumor grade in patients with head and neck squamous cell carcinoma.扩散加权T2成像在预测头颈部鳞状细胞癌患者组织学肿瘤分级中的应用。
Quant Imaging Med Surg. 2022 Aug;12(8):4024-4032. doi: 10.21037/qims-22-136.
4
Extranodal Extension in Bilateral Cervical Metastases: A predictor of Undesirable Survival Outcomes despite Aggressive Salvage Treatment in Oral Cancer Patients.双侧颈部转移瘤的结外侵犯：口腔癌患者尽管接受积极挽救性治疗但生存结果不良的一个预测因素
J Cancer. 2021 Aug 3;12(19):5848-5863. doi: 10.7150/jca.60152. eCollection 2021.
5
CT-Based Radiomics Signature for the Preoperative Discrimination Between Head and Neck Squamous Cell Carcinoma Grades.基于CT的头颈部鳞状细胞癌分级术前鉴别影像组学特征
Front Oncol. 2019 Aug 30;9:821. doi: 10.3389/fonc.2019.00821. eCollection 2019.
6
The current practice of open neck mass biopsy in the diagnosis of head and neck cancer: A retrospective cohort study.开放性颈部肿块活检在头颈部癌症诊断中的当前实践：一项回顾性队列研究。
Laryngoscope Investig Otolaryngol. 2019 Jan 15;4(1):57-61. doi: 10.1002/lio2.240. eCollection 2019 Feb.
7
The utility of MRI histogram and texture analysis for the prediction of histological diagnosis in head and neck malignancies.MRI 直方图和纹理分析在头颈部恶性肿瘤组织学诊断预测中的应用。
Cancer Imaging. 2019 Feb 4;19(1):5. doi: 10.1186/s40644-019-0193-9.
8
The prognostic significance of E-cadherin expression in laryngeal squamous-cell carcinoma: a systematic review.E-钙黏蛋白表达在喉鳞状细胞癌中的预后意义：系统评价。
Acta Otorhinolaryngol Ital. 2018 Dec;38(6):504-510. doi: 10.14639/0392-100X-2106. Epub 2018 Nov 9.
9
Combinational chromosomal aneuploidies and HPV status for prediction of head and neck squamous cell carcinoma prognosis in biopsies and cytological preparations.联合染色体非整倍体和 HPV 状态预测活检和细胞学标本中头颈部鳞状细胞癌的预后。
J Cancer Res Clin Oncol. 2018 Jun;144(6):1129-1141. doi: 10.1007/s00432-018-2629-1. Epub 2018 Mar 20.
10
Relationship of Tumor Thickness with Neck Node Metastasis in Buccal Squamous Cell Carcinoma: An Experience at a Tertiary Care Hospital.颊部鳞状细胞癌肿瘤厚度与颈部淋巴结转移的关系：一家三级护理医院的经验
Int Arch Otorhinolaryngol. 2017 Jul;21(3):265-269. doi: 10.1055/s-0037-1599061. Epub 2017 Feb 21.
本文引用的文献
1
Tumor vascularization, mitotic index, histopathologic grade, and DNA ploidy in the assessment of 114 head and neck squamous cell carcinomas.114例头颈部鳞状细胞癌评估中的肿瘤血管生成、有丝分裂指数、组织病理学分级及DNA倍体分析
Cancer. 1995 Apr 1;75(7):1649-56. doi: 10.1002/1097-0142(19950401)75:7<1649::aid-cncr2820750715>3.0.co;2-e.
2
DNA content and tumor response to induction chemotherapy in patients with advanced laryngeal squamous cell carcinoma.
Otolaryngol Head Neck Surg. 1993 Jun;108(6):731-7. doi: 10.1177/019459989310800616.
3
Prognostic value of histopathological parameters in 51 supraglottic squamous cell carcinomas.51例声门上型鳞状细胞癌组织病理学参数的预后价值
Laryngoscope. 1993 May;103(5):538-40. doi: 10.1288/00005537-199305000-00011.
4
Assessment of tumour vascularity as a prognostic factor in lymph node negative invasive breast cancer.评估肿瘤血管生成作为淋巴结阴性浸润性乳腺癌的一个预后因素。
Eur J Cancer. 1993;29A(8):1141-5. doi: 10.1016/s0959-8049(05)80304-1.
5
Intratumoral microvessel density and p53 protein: correlation with metastasis in head-and-neck squamous-cell carcinoma.肿瘤内微血管密度与p53蛋白：与头颈部鳞状细胞癌转移的相关性
Int J Cancer. 1993 Nov 11;55(5):739-44. doi: 10.1002/ijc.2910550507.
6
Clinical applications of DNA content parameters in patients with squamous cell carcinomas of the head and neck.
Semin Oncol. 1994 Jun;21(3):330-9.
7
Prospective evaluation of cell kinetics in head and neck squamous carcinoma: the relationship to tumour factors and survival.头颈部鳞状细胞癌中细胞动力学的前瞻性评估：与肿瘤因素及生存的关系
Br J Cancer. 1994 Apr;69(4):717-20. doi: 10.1038/bjc.1994.135.
8
Cytokeratin expression in normal and (pre)malignant head and neck epithelia: an overview.细胞角蛋白在正常及（癌前）恶性头颈部上皮中的表达：综述
Head Neck. 1993 Mar-Apr;15(2):133-46. doi: 10.1002/hed.2880150209.
9
Keratins 6, 13 and 19. Differential expression in squamous cell carcinoma of the head and neck.角蛋白6、13和19。在头颈部鳞状细胞癌中的差异表达。
Anal Quant Cytol Histol. 1993 Oct;15(5):335-40.
10
Prognostic value of histopathologic parameters in squamous cell carcinoma of the oropharynx.口咽鳞状细胞癌组织病理学参数的预后价值
Cancer. 1984 Dec 15;54(12):2995-3001. doi: 10.1002/1097-0142(19841215)54:12<2995::aid-cncr2820541230>3.0.co;2-r.
Zotero 插件