Livingston E H, Guth P H
Surgical Service, West Los Angeles VA Medical Center, UCLA.
Life Sci. 1993;52(20):1621-8. doi: 10.1016/0024-3205(93)90043-3.
Prostaglandins of the E series are antisecretory and cytoprotective. Cytoprotection occurs in the deep but not superficial gastric mucosa. It has been hypothesized that the mechanism of cytoprotection involves increased gastric mucosal blood flow (GMBF). However, basal and stimulated gastric mucosal blood flow is greater in the deep than superficial corpus mucosa. The purpose of this study was to investigate the effect of a prostaglandin E2 analog, enprostil, on GMBF in the deep mucosa, where cytoprotection is observed, in both antisecretory and cytoprotective doses. Gastric mucosal blood flow in the deep half of the mucosa was measured by the hydrogen gas clearance method before, during and after intragastric perfusion of enprostil, 0.1-100 micrograms/kg, in urethane anesthetized rats. Enprostil did not alter GMBF in any of the doses tested. Therefore, the cytoprotective action of enprostil is mediated by factors other than a primary increase in GMBF.
E 系列前列腺素具有抗分泌和细胞保护作用。细胞保护作用发生在胃黏膜深层而非表层。据推测，细胞保护机制涉及胃黏膜血流量（GMBF）增加。然而，胃黏膜深层的基础和刺激状态下的血流量均高于胃体黏膜表层。本研究的目的是探讨前列腺素 E2 类似物恩前列素在抗分泌剂量和细胞保护剂量下，对观察到有细胞保护作用的深层黏膜中 GMBF 的影响。在氨基甲酸乙酯麻醉的大鼠中，通过氢气清除法在胃内灌注 0.1 - 100 微克/千克恩前列素之前、期间和之后，测量黏膜深层一半的胃黏膜血流量。恩前列素在所测试的任何剂量下均未改变 GMBF。因此，恩前列素的细胞保护作用是由 GMBF 原发性增加以外的因素介导的。
