Yan C D, Gu L, Tian S P, Chen Q S, Dai Y L, Li D S
Department of Physiology, Nanjing Medical University.
Sheng Li Xue Bao. 1996 Oct;48(5):469-76.
By the use of hydrogen gas clearance technique, we have investigated the role of GMBF in the adaptive cytoprotection induced by intragastric perfusion with low concentration prior to high concentration of HCl plus ethanol. The results were as follows: (1) intragastric perfusion with low concentration prior to high concentration of HCl plus ethanol led to an adaptive cytoprotection, i.e., the gross and the deep damage were decreased by 47.09% and 44.57% respectively, as compared with those caused by high concentration of HCl plus ethanol alone; correspondingly, GMBF also showed an adaptive hyperemic response, i.e., GMBF was increased by 28.02% as compared with that due to high concentration alone; (2) close arterial infusion of vasopressin blocked the adaptive hyperemic response and abolished the adaptive cytoprotection; (3) intravenous indomethacin reduced the basal GMBF, and abolished both the adaptive hyperemic response and cytoprotection; furthermore, the gross and deep damage were aggravated compared with that caused by high concentration alone. The results showed that the adaptive hyperemic response of gastric mucosa was involved in the adaptive cytoprotection and suggested that the adaptive cytoprotection of endogenous prostaglandin might be partially related to the increase of GMBF.
通过氢气清除技术，我们研究了胃黏膜血流量（GMBF）在高浓度盐酸加乙醇灌胃前先给予低浓度灌胃所诱导的适应性细胞保护中的作用。结果如下：（1）在高浓度盐酸加乙醇灌胃前先给予低浓度灌胃可导致适应性细胞保护，即与单独高浓度盐酸加乙醇所致损伤相比，大体损伤和深部损伤分别减少了47.09%和44.57%；相应地，胃黏膜血流量也呈现适应性充血反应，即与单独高浓度所致相比增加了28.02%；（2）动脉内近距离注入血管加压素可阻断适应性充血反应并消除适应性细胞保护；（3）静脉注射消炎痛可降低基础胃黏膜血流量，并消除适应性充血反应和细胞保护；此外，与单独高浓度所致相比，大体损伤和深部损伤加重。结果表明，胃黏膜的适应性充血反应参与了适应性细胞保护，提示内源性前列腺素的适应性细胞保护可能部分与胃黏膜血流量增加有关。
