Landas S K, Leigh C, Bonsib S M, Layne K
Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City.
Mod Pathol. 1993 Mar;6(2):175-8.
Melanin or a melanin-like pigment was observed in six of 19 pheochromocytomas. The intracellular pigment was Fontana-positive, bleach-labile dark brown to black material and distinct from coincidental hemosiderin and lipochrome. Ultrastructural components of the pigmented tumors include melanosomes and premelanosomes. Two patients with pigmented tumors had associated von Hippel-Lindau syndrome, and one had neurofibromatosis. The occurrence of melanin and melanosomes in pheochromocytoma has not been previously reported in the English literature. It is probably a reflection of the neural crest origin of this neoplasm.
在19例嗜铬细胞瘤中，有6例观察到黑色素或类黑色素。细胞内色素对Fontana染色呈阳性，是一种对漂白不稳定的深棕色至黑色物质，与巧合出现的含铁血黄素和脂褐素不同。色素沉着肿瘤的超微结构成分包括黑素小体和前黑素小体。两名色素沉着肿瘤患者伴有冯·希佩尔-林道综合征，一名患者患有神经纤维瘤病。嗜铬细胞瘤中黑色素和黑素小体的出现此前在英文文献中未见报道。这可能反映了该肿瘤的神经嵴起源。
