Yndestad M, Helgebostad A, Loftsgård G
Acta Vet Scand. 1977;18(1):23-30. doi: 10.1186/BF03548462.
Investigations were performed to determine the exact susceptibility of foxes to Clostridium botulinum type C and E toxins. Doses of 5 mill. MLD type C toxin mixed with the feed did not cause symptoms of botulism in either cubs or adult foxes. Subcutaneous injections of 300,100(0 MLD or more were fatal to cubs, while 750,000 MLD caused the death of all adults. Regarding type E toxin, doses of 1 mill. MLD affected neither cubs nor adults on oral administration. Subcutaneously injected doses of 5,000 MLD or more killed all cubs, while 10,000 MLD was required to produce lethal effect on adult animals. The conclusion made is that foxes are highly resistant to both type C and E Clostridium botulinum toxins following oral application. It is further revealed that foxes are 60–70 times more susceptible to type E than to type C toxin when injected subcutaneously.
开展了调查以确定狐狸对C型和E型肉毒梭菌毒素的确切易感性。将5毫升最小致死量（MLD）的C型毒素与饲料混合投喂，幼狐和成年狐均未出现肉毒中毒症状。皮下注射300、100或更多MLD对幼狐致命，而750,000 MLD可导致所有成年狐死亡。关于E型毒素，口服1毫升MLD对幼狐和成年狐均无影响。皮下注射5,000 MLD或更多剂量可杀死所有幼狐，而对成年动物产生致死作用则需要10,000 MLD。得出的结论是，经口服，狐狸对C型和E型肉毒梭菌毒素均具有高度抗性。进一步发现，皮下注射时，狐狸对E型毒素的易感性比对C型毒素高60至70倍。
