Arana-Trejo R M, Cervantes-Peredo A, Rozen E, Kassack J J, Gutiérrez M, Kofman-Alfaro S
Servicio de Genética, Hospital General de México SSa, D.F.
Rev Invest Clin. 1993 Jan-Feb;45(1):43-8.
Between 1987 and 1990 cytogenetic studies of bone marrow and lymphocytes from peripheral blood from 25 patients with de novo ALL were performed. All cases had chromosomal aberrations; however in 23 patients a normal cell line was also present. The most important structural aberrations found were: t(17;19)(q11;p13), t(2;9;22)(q34;q34;11), t(1;7)(p13;q33), t(6;11)(q26;p16), t(3;4)(q24-25;q26), t(1;12)(q23;q34), t(2;18)(q15;p12), t(2;4)(q23;q35) and t(4;11)(q21;q23). These chromosome abnormalities correlate with the response to treatment and survival and improve the identification of high-risk patients. Our study shows the presence of some chromosomal abnormalities different to those reported in the literature; however the breakpoints involved seem to be the same which suggests that these critical regions may be directly involved in the pathogenesis of these disorders.
1987年至1990年间，对25例初发急性淋巴细胞白血病患者的骨髓和外周血淋巴细胞进行了细胞遗传学研究。所有病例均有染色体畸变；然而，23例患者中也存在正常细胞系。发现的最重要的结构畸变有：t(17;19)(q11;p13)、t(2;9;22)(q34;q34;11)、t(1;7)(p13;q33)、t(6;11)(q26;p16)、t(3;4)(q24 - 25;q26)、t(1;12)(q23;q34)、t(2;18)(q15;p12)、t(2;4)(q23;q35)和t(4;11)(q21;q23)。这些染色体异常与治疗反应和生存相关，并有助于高危患者的识别。我们的研究显示存在一些与文献报道不同的染色体异常；然而，所涉及的断点似乎相同，这表明这些关键区域可能直接参与了这些疾病的发病机制。
