Casanova-Cardiel L J, Ruiz-Ordaz I
Servicio de Infectología Adultos, Hospital de Infectología, Centro Médico La Raza, IMSS, México, D.F.
Rev Invest Clin. 1993 Jan-Feb;45(1):67-70.
This paper describes the clinical course of four patients with AIDS who were found to have H capsulatum in peripheral blood. The evolution of the infection was fulminant and all died within the first 96 hours following hospitalization. In every case the presence of the characteristic mycelium and "tuberculate" macroconidia of Histoplasma was established in cultures. All cases showed the hematological abnormalities common in other AIDS associated diseases. In addition, there was an increase in serum lactic dehydrogenase over ten times our normal level: the lowest LDM assay was 2137 IU/mL and the highest 4839 IU/mL. This clinical course resembling septicemia and the demonstration of H capsulatum in a peripheral blood smear has had a rate of 12% in our experience (four out of the 34 cases of AIDS with histoplasmosis seen in our institution from January 1984 to March 1991).
本文描述了4例艾滋病患者的临床病程，这些患者外周血中发现荚膜组织胞浆菌。感染进展迅猛，所有患者均在住院后的前96小时内死亡。每例患者的培养物中均发现了荚膜组织胞浆菌特征性的菌丝体和“结节状”大分生孢子。所有病例均表现出其他艾滋病相关疾病常见的血液学异常。此外，血清乳酸脱氢酶升高超过正常水平的10倍：乳酸脱氢酶检测的最低值为2137 IU/mL，最高值为4839 IU/mL。在我们的经验中，这种类似败血症的临床病程以及在外周血涂片上发现荚膜组织胞浆菌的情况发生率为12%（1984年1月至1991年3月在我们机构诊治的34例艾滋病合并组织胞浆菌病患者中有4例）。
