通过抗独特型抗体检测到的生发中心细胞的寡克隆发育。
Oligoclonal development of germinal centre cells as detected by anti-idiotype antibodies.
作者信息
De Jong D, Cramer G, Brand A, Kluin P M
机构信息
Laboratory of Pathology, University of Leiden, The Netherlands.
出版信息
Scand J Immunol. 1993 May;37(5):602-4. doi: 10.1111/j.1365-3083.1993.tb02578.x.
Experimental models using immunization with known haptens have shown that germinal centres develop from only a limited number of precursor cells which expand in an oligoclonal fashion. Using a panel of antibodies raised against the idiotype of follicle centre cell lymphomas and known to be reactive only with a few normal B cells, we could demonstrate that individual clones can be identified within germinal centres of individual follicles of human lymph nodes and tonsils. Therefore also in humans in a non-experimental, natural situation, germinal centres expand in an oligoclonal fashion.
使用已知半抗原进行免疫的实验模型表明，生发中心仅由少数以寡克隆方式扩增的前体细胞发育而来。利用一组针对滤泡中心细胞淋巴瘤独特型产生的抗体，且已知这些抗体仅与少数正常B细胞发生反应，我们能够证明在人淋巴结和扁桃体的单个滤泡的生发中心内可以识别出单个克隆。因此，在非实验性的自然情况下，人类的生发中心也是以寡克隆方式扩增的。
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