通往Ras的众多途径。 - Suppr

The many roads that lead to Ras.

作者信息

Feig L A

机构信息

Department of Biochemistry, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111.

出版信息

Science. 1993 May 7;260(5109):767-8. doi: 10.1126/science.8484117.

DOI:10.1126/science.8484117

PMID:8484117

Abstract

摘要

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The many roads that lead to Ras.通往Ras的众多途径。

Science. 1993 May 7;260(5109):767-8. doi: 10.1126/science.8484117.

Raf-1 interferes with Ras and Rap1A effector functions in yeast.Raf-1在酵母中干扰Ras和Rap1A效应器功能。

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A mouse CDC25-like product enhances the formation of the active GTP complex of human ras p21 and Saccharomyces cerevisiae RAS2 proteins.一种小鼠CDC25样产物可增强人源ras p21和酿酒酵母RAS2蛋白活性GTP复合物的形成。

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Residues crucial for Ras interaction with GDP-GTP exchangers.对Ras与GDP-GTP交换因子相互作用至关重要的残基。

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Saccharomyces cerevisiae CDC25 (1028-1589) is a guanine nucleotide releasing factor for mammalian ras proteins and is oncogenic in NIH3T3 cells.酿酒酵母CDC25（1028 - 1589）是一种针对哺乳动物ras蛋白的鸟嘌呤核苷酸释放因子，在NIH3T3细胞中具有致癌性。

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Enhancement of the GDP-GTP exchange of RAS proteins by the carboxyl-terminal domain of SCD25.SCD25的羧基末端结构域对RAS蛋白GDP-GTP交换的增强作用。

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Comparison of kinetic properties between two mammalian ras p21 GDP/GTP exchange proteins, ras guanine nucleotide-releasing factor and smg GDP dissociation stimulation.两种哺乳动物ras p21 GDP/GTP交换蛋白（ras鸟嘌呤核苷酸释放因子和smg GDP解离刺激因子）之间动力学特性的比较

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New genes may shed light on cell growth control.新基因可能有助于揭示细胞生长控制机制。

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Eukaryotic RAS proteins and yeast proteins with which they interact.真核生物RAS蛋白及其相互作用的酵母蛋白。

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Ras-regulated signaling processes in Saccharomyces cerevisiae.酿酒酵母中Ras调节的信号传导过程。

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Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation.与糖尿病相关的Ras相关蛋白（rad）与假定的肿瘤转移抑制因子NM23之间的相互作用提供了一种GTP酶调节的新机制。

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Tumor promoter arsenite activates extracellular signal-regulated kinase through a signaling pathway mediated by epidermal growth factor receptor and Shc.肿瘤启动子亚砷酸盐通过由表皮生长因子受体和Shc介导的信号通路激活细胞外信号调节激酶。

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Correlation of alpha-fetoprotein expression in normal hepatocytes during development with tyrosine phosphorylation and insulin receptor expression.发育过程中正常肝细胞中甲胎蛋白表达与酪氨酸磷酸化及胰岛素受体表达的相关性。

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The E5 gene product of rhesus papillomavirus is an activator of endogenous Ras and phosphatidylinositol-3'-kinase in NIH 3T3 cells.恒河猴乳头瘤病毒的E5基因产物是NIH 3T3细胞中内源性Ras和磷脂酰肌醇 - 3'-激酶的激活剂。

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TC21 causes transformation by Raf-independent signaling pathways.TC21 通过不依赖Raf的信号通路引起细胞转化。

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The selectins: insights into selectin-induced intracellular signaling in leukocytes.选择素：对白细胞中选择素诱导的细胞内信号传导的见解。

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Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation.致癌性Ras对Raf/丝裂原活化蛋白激酶非依赖途径的激活足以导致致瘤性转化。

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The many roads that lead to Ras.

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