18-Substituted steroids. Part 18. Chemical synthesis and mineralocorticoid activity of 2 alpha- and 2 beta-hydroxyaldosterone.
作者信息
Kirk D N, Schröder M H, Latif S A, Souness G W, Morris D J
机构信息
Department of Chemistry, Queen Mary and Westfield College, London, UK.
出版信息
Steroids. 1993 Feb;58(2):59-63. doi: 10.1016/0039-128x(93)90053-p.
PMID:8484185
Abstract
The 2 alpha-hydroxy and 2 beta-hydroxy derivatives of aldosterone have been synthesized chemically from aldosterone, after the earlier identification of 2 alpha-hydroxylated metabolites formed in liver. Both 2 alpha- and 2 beta-hydroxyaldosterone are potent mineralocorticoids, with activities on the order of 1/10 that of aldosterone on the basis of a rat bioassay.
摘要
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