Kirk D N, Burke P J, Toms H C, Latif S A, Morris D J
Department of Chemistry, Queen Mary College, London, UK.
Steroids. 1989 Aug;54(2):169-84. doi: 10.1016/0039-128x(89)90092-5.
6 beta-Hydroxyaldosterone and 6 beta-hydroxy-17-isoaldosterone, characterized by high-field NMR studies, are among the major polar metabolites formed from aldosterone by incubation with rat liver slices or microsomal fraction. It is uncertain at present whether the 17-iso product results from an enzymatic or a chemical inversion of configuration. Periodate degradation of the 6 beta-hydroxyaldosterone gave 6 beta-hydroxyaldosterone gamma-lactone, identical with a synthetic sample.
通过高场核磁共振研究表征的6β-羟基醛固酮和6β-羟基-17-异醛固酮，是醛固酮与大鼠肝切片或微粒体部分孵育形成的主要极性代谢产物。目前尚不确定17-异产物是由构型的酶促转化还是化学转化产生的。6β-羟基醛固酮的高碘酸盐降解产生了6β-羟基醛固酮γ-内酯，与合成样品相同。
