Prichard R K, Ranjan S
Institute of Parasitology, McGill University, Ste-Anne-de-Bellevue, Que., Canada.
Vet Parasitol. 1993 Feb;46(1-4):113-20. doi: 10.1016/0304-4017(93)90052-o.
Anthelmintics remain the principal means for the prevention and control of subclinical and clinical ostertagiasis. The selection of an appropriate anthelmintic depends on whether one is controlling or preventing Type I ostertagiasis (caused by the establishment of adult worms derived from recently acquired infective larvae), preventing Type II (treating pre-Type II or inhibited larvae) or controlling Type II ostertagiasis (caused by the development of inhibited larvae to adults), or using the anthelmintic as part of an epidemiologically based plan to reduce pasture contamination with infective Ostertagia ostertagi larvae. In the latter case, the choice of an anthelmintic may depend on whether the targets for treatment are only adult worms and developing larvae or whether the targets include hypobiotic larvae. Thus for Ostertagia control, anthelmintics must be divided into those that normally control all stages, such as the avermectin group (ivermectin, abamectin and moxidectin) and some of the benzimidazoles (albendazole, oxfendazole and fenbendazole at appropriate dose rates), and those that only control adult worms and developing larvae (levamisole, morantel, coumaphos, phenothiazine and thiabendazole).
驱虫药仍然是预防和控制亚临床型和临床型奥斯特他线虫病的主要手段。选择合适的驱虫药取决于使用者是要控制还是预防I型奥斯特他线虫病（由近期获得的感染性幼虫发育为成虫所致）、预防II型（治疗II型前期或受抑制的幼虫）、控制II型奥斯特他线虫病（由受抑制的幼虫发育为成虫所致），还是将驱虫药作为基于流行病学的计划的一部分以减少感染性奥斯特他线虫幼虫对牧场的污染。在后一种情况下，驱虫药的选择可能取决于治疗目标仅是成虫和发育中的幼虫，还是也包括休眠幼虫。因此，对于控制奥斯特他线虫病而言，驱虫药必须分为通常能控制所有阶段的药物，如阿维菌素类（伊维菌素、阿维菌素和莫西菌素）以及某些苯并咪唑类（阿苯达唑、奥芬达唑和芬苯达唑在适当剂量下），和仅能控制成虫和发育中的幼虫的药物（左旋咪唑、莫仑太尔、蝇毒磷、吩噻嗪和噻苯达唑）。
