Kirste G
Chirurgische Klinik, Albert-Ludwigs-Universität Freiburg.
Zentralbl Chir. 1993;118(3):113-7.
Since the first successful procedure in 1954 kidney transplantation has become a standard therapy of end stage renal disease. The knowledge of immunoregulation and immune response of the body has enabled people to recognize acute rejection of organs. HLA-testing and organ exchange on basis of HLA-compatibility are extremely important for a successful kidney transplantation. A shortage of organs is limiting the further increase of transplantations. Chronic rejection is in most cases the reason for late graft failure. Further investigations to develop new immunosuppressive drugs and to clarify immunological processes underlying chronic rejections are necessary in the future.
自1954年首例成功的肾脏移植手术以来，肾脏移植已成为终末期肾病的标准治疗方法。对机体免疫调节和免疫反应的认识使人们能够识别器官的急性排斥反应。HLA检测以及基于HLA相容性的器官交换对于成功的肾脏移植极为重要。器官短缺限制了移植数量的进一步增加。在大多数情况下，慢性排斥反应是移植肾晚期失功的原因。未来有必要开展进一步研究以开发新的免疫抑制药物，并阐明慢性排斥反应背后的免疫过程。
