Koo A, Li K M
Am J Chin Med (Gard City N Y). 1977 Spring;5(1):31-7. doi: 10.1142/s0192415x7700004x.
An improved extraction method was used to obtain hypotensive principles from seeds of Gardenia jasminoides Ellis (Rubiaceae). The crude extract contained mainly glycosides and had minimal direct cardiac depressant effects. The hypotensive action was attributable to a reflex phenomenon, involving both the parasympathetic and the sympathetic vasomotor centers. It was shown that the hypotensive and bradycardiac properties of Gardenia extract were entirely abolished in a tropinized and vagotomized rats, but only partially attenuated in carotid sinus denervated rats, and that low cervical spinal transection in rats did not inhibit the hypotensive responses. Accordingly, the afferent limb of this cardiovascular reflex are consisted of both vagus nerves and baroreceptor afferents, whereas the vagi alone constituted the efferent limb.
采用一种改进的提取方法从茜草科栀子的种子中获取降压成分。粗提取物主要含有糖苷，对心脏的直接抑制作用极小。其降压作用归因于一种反射现象，涉及副交感神经和交感神经血管运动中枢。结果表明，在给予阿托品和切断迷走神经的大鼠中，栀子提取物的降压和心动过缓特性完全消失，但在切断颈动脉窦神经的大鼠中仅部分减弱，并且大鼠低位颈髓横断并不抑制降压反应。因此，这种心血管反射的传入支由迷走神经和压力感受器传入纤维组成，而传出支仅由迷走神经构成。
