Gutiérrez C B, Píriz S, Vadillo S, Rodríguez Ferri E F
Unidad de Microbiología e Inmunología, Falcultad de Veterinaria, Universidad de León, Spain.
Am J Vet Res. 1993 Apr;54(4):546-50.
Minimal inhibitory concentration of 42 antimicrobial agents was determined against 57 field strains of Actinobacillus pleuropneumoniae isolated from pigs in Spain. Penicillins, aminoglycosides, and tetracyclines had irregular activity; ticarcillin, tobramycin, and doxycycline were the most active of each group, respectively. Macrolides, vancomycin, dapsone, and tiamulin, to which strains had high rate of resistance, were almost ineffective. Thiamphenicol, colistin, rifampin, fosfomycin, mupirocin, and metronidazole had good activity, with resistance ranging between 0 and 8.8%. Finally, cephalosporins (except cephalexin) and quinolones (especially ciprofloxacin, enrofloxacin, and sparfloxacin) were the most active antibiotics against A pleuropneumoniae.
测定了42种抗菌剂对从西班牙猪群中分离出的57株胸膜肺炎放线杆菌田间菌株的最低抑菌浓度。青霉素、氨基糖苷类和四环素类的活性不规则；替卡西林、妥布霉素和强力霉素分别是每组中活性最强的。菌株对大环内酯类、万古霉素、氨苯砜和泰妙菌素耐药率高，几乎无效。甲砜霉素、黏菌素、利福平、磷霉素、莫匹罗星和甲硝唑活性良好，耐药率在0%至8.8%之间。最后，头孢菌素类（除头孢氨苄外）和喹诺酮类（尤其是环丙沙星、恩诺沙星和司帕沙星）是对抗胸膜肺炎放线杆菌活性最强的抗生素。
