Gilger B C, Whitley R D, McLaughlin S A, Wright J C, Boosinger T R
Department of Small Animal Surgery, College of Veterinary Medicine, Auburn University, AL 36849-5523.
Am J Vet Res. 1993 Apr;54(4):616-21.
Clinical findings indicate that canine eyes tolerate implantation of polymethylmethacrylate (PMMA) intraocular lenses (IOL) well, although inflammation and ocular damage attributable to the implants is not known. The use of silicone or polyhydroxyethylmethacrylate (HEMA) IOL has not been reported in dogs. In this study, 15 conditioned, mixed-breed dogs were allotted to 3 groups: 5 received PMMA IOL; 5 received silicone IOL; and 5 received HEMA IOL. The IOL optic was inserted into the anterior chamber of the right eye and anchored to the cornea. An identical surgical procedure was done on the left eye, except that no lens optic was inserted. Clinical examination and measurement of corneal thickness were done immediately prior to and after surgery. Aqueous humor samples were collected at the time of surgery and 28 days after surgery. Only mild and transient inflammation was observed in IOL-implanted eyes. On several postoperative days, it was found that PMMA IOL induced significantly greater corneal thickness, aqueous flare, anterior uveal irritation, and corneal edema than did other IOL. Significantly more anterior uveal irritation and increased aqueous humor protein concentration was observed with HEMA IOL than with PMMA or silicone IOL. Silicone IOL induced significantly less fibrin deposition than did PMMA or HEMA IOL.
临床研究结果表明，犬眼对聚甲基丙烯酸甲酯（PMMA）人工晶状体（IOL）植入的耐受性良好，不过植入物导致的炎症和眼损伤情况尚不清楚。尚未有关于犬使用硅胶或聚甲基丙烯酸羟乙酯（HEMA）人工晶状体的报道。在本研究中，15只经训练的杂种犬被分为3组：5只植入PMMA人工晶状体；5只植入硅胶人工晶状体；5只植入HEMA人工晶状体。将人工晶状体光学部插入右眼前房并固定于角膜。左眼进行相同的手术操作，但不植入晶状体光学部。在手术前后即刻进行临床检查和角膜厚度测量。在手术时及术后28天采集房水样本。在植入人工晶状体的眼中仅观察到轻度和短暂的炎症。在术后数天发现，与其他人工晶状体相比，PMMA人工晶状体导致的角膜厚度增加、房水闪光、前葡萄膜刺激和角膜水肿更为显著。与PMMA或硅胶人工晶状体相比，HEMA人工晶状体观察到的前葡萄膜刺激和房水蛋白浓度增加更为明显。硅胶人工晶状体诱导的纤维蛋白沉积明显少于PMMA或HEMA人工晶状体。
