Welsh C H, Wagner P D, Reeves J T, Lynch D, Cink T M, Armstrong J, Malconian M K, Rock P B, Houston C S
Department of Medicine, University of Colorado Health Sciences Center, Denver.
Am Rev Respir Dis. 1993 May;147(5):1239-44. doi: 10.1164/ajrccm/147.5.1239.
We report spirometry and radiographic data on eight normal male human subjects during prolonged graded altitude exposure to as high as 8,848 m above sea level in a hypobaric chamber. We found a significant and progressive drop in FVC by 14 +/- 3% over 40 days, which resolved slowly during the first 48 h after descent. With altitude, midrange forced expiratory flow (FEF25-75) increased by 82 +/- 3%, probably because of reduced air density. FEV1, however, did not change. Chest radiographs on subjects taken 2 h after descent to sea level showed a pattern of pulmonary artery enlargement and interstitial edema. These data suggest that increased pulmonary blood volume and edema may be causes of the restricted pulmonary function pattern.
我们报告了八名正常男性受试者在低压舱中长时间分级暴露于高达海拔8848米的高原环境下的肺功能测定和影像学数据。我们发现，在40天内，用力肺活量（FVC）显著且逐渐下降了14±3%，在下降后的最初48小时内缓慢恢复。随着海拔升高，中期用力呼气流量（FEF25-75）增加了82±3%，这可能是由于空气密度降低所致。然而，第一秒用力呼气容积（FEV1）没有变化。受试者下降到海平面2小时后拍摄的胸部X光片显示出肺动脉扩大和间质性水肿的模式。这些数据表明，肺血容量增加和水肿可能是肺功能受限模式的原因。
