L37的一级结构——一种具有锌指样基序的大鼠核糖体蛋白。
The primary structure of L37--a rat ribosomal protein with a zinc finger-like motif.
作者信息
Chan Y L, Paz V, Olvera J, Wool I G
机构信息
Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637.
出版信息
Biochem Biophys Res Commun. 1993 Apr 30;192(2):590-6. doi: 10.1006/bbrc.1993.1456.
The amino acid sequence of the rat 60S ribosomal subunit protein L37 was deduced from the sequence of nucleotides in a recombinant cDNA. Ribosomal protein L37 has 96 amino acids, the NH2-terminal methionine is removed after translation of the mRNA, and has a molecular weight of 10,939. Ribosomal protein L37 has a single zinc finger-like motif of the C2-C2 type. Hybridization of the cDNA to digests of nuclear DNA suggests that there are 13 or 14 copies of the L37 gene. The mRNA for the protein is about 500 nucleotides in length. Rat L37 is related to Saccharomyces cerevisiae ribosomal protein YL35 and to Caenorhabditis elegans L37. We have identified in the data base a DNA sequence that encodes the chicken homolog of rat L37.
大鼠60S核糖体亚基蛋白L37的氨基酸序列是从重组cDNA中的核苷酸序列推导出来的。核糖体蛋白L37有96个氨基酸，mRNA翻译后其氨基末端的甲硫氨酸被去除，分子量为10939。核糖体蛋白L37具有单个C2 - C2型锌指样基序。cDNA与核DNA消化产物的杂交表明L37基因有13或14个拷贝。该蛋白的mRNA长度约为500个核苷酸。大鼠L37与酿酒酵母核糖体蛋白YL35和秀丽隐杆线虫L37相关。我们在数据库中鉴定出了一个编码大鼠L37鸡同源物的DNA序列。
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