Chambers K C, Sengstake C B, Brownson E A, Westfahl P K
Department of Psychology, University of Southern California, Los Angeles 90089.
Behav Neurosci. 1993 Apr;107(2):299-305. doi: 10.1037//0735-7044.107.2.299.
The hypothesis that fluid deprivation accelerates extinction of a conditioned taste aversion in male Sprague-Dawley-derived rats by reducing serum testosterone levels was tested. Serum testosterone levels were found to be lower in fluid-deprived males than in nondeprived males (Experiments 1 and 2). Exogenous testosterone treatment that results in high physiological levels of serum testosterone slowed the extinction of fluid-deprived gonadectomized males to rates comparable with those of nondeprived sham males (Experiment 3). It was noted, however, that testosterone treatment was less effective in slowing extinction in fluid-deprived gonadectomized males than in nondeprived gonadectomized males even though the serum testosterone levels were the same (Experiments 3 and 4). These results provide strong support for the original hypothesis, but they suggest that fluid deprivation also reduces sensitivity to testosterone.
对“通过降低血清睾酮水平，禁水会加速雄性斯普拉格 - 道利大鼠条件性味觉厌恶的消退”这一假设进行了测试。结果发现，禁水雄性大鼠的血清睾酮水平低于未禁水的雄性大鼠（实验1和2）。外源性睾酮治疗使血清睾酮达到高生理水平，减缓了禁水去势雄性大鼠的消退速度，使其与未禁水假手术雄性大鼠的消退速度相当（实验3）。然而，值得注意的是，尽管血清睾酮水平相同，但睾酮治疗在减缓禁水去势雄性大鼠消退方面的效果不如未禁水去势雄性大鼠（实验3和4）。这些结果为原假设提供了有力支持，但也表明禁水还会降低对睾酮的敏感性。
