一氧化氮对人离体逼尿肌条在电场刺激下舒张反应的部分介导作用。
Partial mediation by nitric oxide of the relaxation of human isolated detrusor strips in response to electrical field stimulation.
作者信息
James M J, Birmingham A T, Hill S J
机构信息
Department of Physiology and Pharmacology, University of Nottingham Medical School, Queen's Medical Centre.
出版信息
Br J Clin Pharmacol. 1993 Apr;35(4):366-72. doi: 10.1111/j.1365-2125.1993.tb04152.x.
Abstract
- A method for reproducing relaxation of human isolated detrusor smooth muscle in vitro in response to electrical field stimulation is described. 2. The parameters of stimulation associated with relaxation were those which would be expected to give a largely nerve-mediated response: the relaxations were not reduced by tetrodotoxin (3 x 10(-7) M) and were therefore not dependent on voltage sensitive sodium channels. 3. The relaxations were decreased (mean 74.1%) by nitro L-arginine (NOARG, 10(-5) M). 4. Methylene blue (10(-5) M), an inhibitor of soluble guanylate cyclase, abolished the relaxations. 5. These results indicate that there may be a relaxation mechanism in the human bladder which is at least partly mediated via the production of nitric oxide.
摘要
- 描述了一种在体外重现人离体逼尿肌平滑肌对电场刺激产生舒张反应的方法。2. 与舒张相关的刺激参数是那些预期能产生主要由神经介导反应的参数：河豚毒素（3×10⁻⁷ M）不会降低舒张反应，因此其不依赖于电压敏感性钠通道。3. 硝基-L-精氨酸（NOARG，10⁻⁵ M）可使舒张反应降低（平均74.1%）。4. 可溶性鸟苷酸环化酶抑制剂亚甲蓝（10⁻⁵ M）可消除舒张反应。5. 这些结果表明，人膀胱中可能存在一种舒张机制，其至少部分是通过一氧化氮的产生介导的。
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