Bain B J
Department of Haematology, St Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London.
Br J Haematol. 1993 Mar;83(3):516-8. doi: 10.1111/j.1365-2141.1993.tb04679.x.
The blood films of patients with sickle cell-haemoglobin C disease (SC) were compared with those of patients with related haemoglobinopathies in order to establish the most characteristic features. The blood films from SC patients generally permitted the distinction from sickle cell anaemia (SS) but not necessarily from haemoglobin C disease (CC) or C/beta thalassaemia. About half of the SC films showed characteristic SC poikilocytes and a minority also had some cells containing haemoglobin C crystals. In addition, SC differed from SS in having fewer classical sickle cells and nucleated red cells, more irregularly-contracted cells and less polychromasia and evidence of hyposplenism.
为确定镰状细胞-血红蛋白C病（SC）患者的最特征性表现，将其血涂片与相关血红蛋白病患者的血涂片进行了比较。SC患者的血涂片通常有助于与镰状细胞贫血（SS）相区分，但不一定能与血红蛋白C病（CC）或C/β地中海贫血相区分。约一半的SC血涂片显示出特征性的SC异形红细胞，少数血涂片中也有一些含有血红蛋白C晶体的细胞。此外，SC与SS的不同之处在于，SC的典型镰状细胞和有核红细胞较少，不规则收缩细胞较多，多色性较少，且有脾功能减退的迹象。
