Park Y K, Hann S K, Im S, Kim S
Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea.
J Dermatol Sci. 1993 Feb;5(1):19-24. doi: 10.1016/0923-1811(93)90101-t.
The skin concentrations of 8-methoxypsoralen (8-MOP), 5-methoxypsoralen (5-MOP) and 4,5,8-trimethylpsoralen (TMP) were studied in the albino guinea pig following oral administration and intraperitoneal injection. The skin concentration of phototoxic drugs after oral administration peaked at 1.5 h, and the concentration of 8-MOP was 3.5 times greater than that of 5-MOP. The skin concentration of TMP was not detected in our study (limit of sensitivity 5 ng/ml). The highest skin concentrations of 8-MOP and 5-MOP after intraperitoneal injection were achieved for both drugs at 0.5 h, with the level of 8-MOP approximately 1.3 times higher than that of 5-MOP. The level of TMP could not be measured even in the case of intraperitoneal injection.
对白化豚鼠口服和腹腔注射后，研究了8-甲氧基补骨脂素（8-MOP）、5-甲氧基补骨脂素（5-MOP）和4,5,8-三甲基补骨脂素（TMP）的皮肤浓度。口服光毒性药物后皮肤浓度在1.5小时达到峰值，8-MOP的浓度比5-MOP高3.5倍。在我们的研究中未检测到TMP的皮肤浓度（灵敏度极限为5 ng/ml）。腹腔注射后，8-MOP和5-MOP在0.5小时时皮肤浓度均达到最高，8-MOP的水平比5-MOP高约1.3倍。即使在腹腔注射的情况下，也无法测量TMP的水平。
