多种光毒性药物给药后皮肤浓度的研究。

Study of the skin concentrations after administration of the various phototoxic drugs.

作者信息

Park Y K, Hann S K, Cho M Y, Kim H J, Shim S C, Choi S J, Yun M H

机构信息

Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea.

出版信息

Yonsei Med J. 1991 Sep;32(3):231-6. doi: 10.3349/ymj.1991.32.3.231.

DOI:10.3349/ymj.1991.32.3.231

PMID:1781182

Abstract

The skin concentrations of 8-methoxypsoralen (8-MOP), 5-methoxypsoralen (5-MOP), and 4, 5', 8-trimethylpsoralen (TMP) were studied in the guinea pig following oral administration and bathing. The skin concentration of phototoxic drugs after oral administration peaked at 1.5 hours, and the concentration of 8-MOP was 3.5 times greater than that of 5-MOP. The skin concentration of TMP was not detected in our study (limit of sensitivity 5ng/ml). The skin concentrations of phototoxic drug after bathing decreased in the order of 5-MOP, TMP, and 8-MOP.

摘要

研究了豚鼠口服及沐浴后8-甲氧基补骨脂素（8-MOP）、5-甲氧基补骨脂素（5-MOP）和4,5',8-三甲基补骨脂素（TMP）的皮肤浓度。口服光毒性药物后皮肤浓度在1.5小时达到峰值，8-MOP的浓度比5-MOP高3.5倍。在我们的研究中未检测到TMP的皮肤浓度（灵敏度限值为5ng/ml）。沐浴后光毒性药物的皮肤浓度按5-MOP、TMP和8-MOP的顺序降低。