Coulais Y, Cros G, Darbieu M H, Gantet P, Tafani J A, Vende D, Pasqualini R, Guiraud R
Laboratoire de Biophysique et de Médecine Nucléaire, Faculté de Médecine Toulouse-Purpan, France.
Nucl Med Biol. 1993 Apr;20(3):263-8. doi: 10.1016/0969-8051(93)90047-x.
Three unsaturated Schiff base tetradentate (N2S2 or N2SO) ligands were synthesized and characterized. Oxo and nitrido 99m-technetium complexes were obtained with these ligands. The nitrido complexes were formed using a new easy method available as a kit. When injected into rats and mice, these lipophilic complexes were able to cross the blood-brain barrier but brain perfusion imaging could not be performed due to the insufficient uptake and retention time.
合成并表征了三种不饱和席夫碱四齿（N2S2或N2SO）配体。用这些配体制备了氧代和氮代99m-锝配合物。氮代配合物采用一种新的简便方法制备，该方法可作为试剂盒使用。当将这些亲脂性配合物注射到大鼠和小鼠体内时，它们能够穿过血脑屏障，但由于摄取量不足和保留时间不够，无法进行脑灌注成像。
