脂肪酸反向扩散对用123-碘十六碳烯酸在离体大鼠心脏中获得的外部检测曲线的房室分析的影响。

Influence of fatty acid backdiffusion on compartmental analysis of external detection curves obtained with 123-iodohexadecenoic acid in isolated rat heart.

作者信息

Garnier A, Dubois F, Keriel C, Poizat C, Cand F, Cuchet P

机构信息

Laboratoire de Physiologie Cellulaire Cardiaque, Université Joseph Fourier, Grenoble, France.

出版信息

Nucl Med Biol. 1993 Apr;20(3):297-306. doi: 10.1016/0969-8051(93)90051-u.

DOI:10.1016/0969-8051(93)90051-u

PMID:8485489

Abstract

In isolated rat hearts, we investigated a possible backdiffusion of fatty acids and tried to determine whether it impaired our compartmental analysis of myocardial time-radioactivity curves obtained with an iodinated fatty acid, 16-iodo-9-hexadecenoic acid (IHA). Backdiffusion was not observed directly in the coronary effluents but was estimated by analysis of the external detection curves. Furthermore, when backdiffusion was not taken into account in the mathematical analysis, we obtained similar data on IHA intramyocardial metabolism.

摘要

在离体大鼠心脏中，我们研究了脂肪酸可能的反向扩散，并试图确定其是否会影响我们对用碘化脂肪酸16-碘-9-十六碳烯酸（IHA）获得的心肌时间-放射性曲线的房室分析。在冠状动脉流出液中未直接观察到反向扩散，但通过对外部检测曲线的分析进行了估计。此外，当在数学分析中不考虑反向扩散时，我们获得了关于IHA心肌内代谢的类似数据。