Van Bree J B, De Boer A G, Danhof M, Breimer D D
Leiden/Amsterdam Center for Drug Research, Division of Pharmacology, Leiden University, The Netherlands.
Pharm World Sci. 1993 Feb 19;15(1):2-9. doi: 10.1007/BF02116163.
This is the third part of a review on the transport of drugs across the blood-brain barrier. In the first two parts, the anatomical and physiological aspects and the various techniques that can be used to study blood-brain transport have been discussed and reviewed. This third part focuses specifically on the mechanisms that are involved in drug transport across the blood-brain barrier. In addition, the opportunities to improve drug transport into the brain will be reviewed. Emphasis is on the transport of peptides.
这是一篇关于药物透过血脑屏障转运的综述的第三部分。在前两部分中，已对血脑屏障的解剖学和生理学方面以及可用于研究血脑转运的各种技术进行了讨论和综述。第三部分专门聚焦于药物透过血脑屏障所涉及的机制。此外，还将综述改善药物向脑内转运的机会。重点是肽类的转运。
