Matousovic K, Rossmann P
Klinika nefrologie Institutu klinické a experimentální medicíny, Praha.
Cas Lek Cesk. 1993 Mar 22;132(6):174-7.
Antiglomerular basement membrane glomerulonephritis was diagnosed in 14 patients (6 men and 8 women) aged 20 to 59 years. Five patients were found to have Goodpasture s syndrome. 5 rapidly progressive glomerulonephritis. 1 nephrotic syndrome, and 1 had mild glomerulonephritis. Blood pressure, proteinuria and haematuria were not severe in most patients. In 10 patients, the diagnosis was not established before end-stage renal failure had developed. Four patients died of lung haemorrhage, in 3 the haemorrhage was controlled by the treatment, in 3 renal failure without lung haemorrhage occurred, and in 3 renal function improved or was stable. The prognosis improved significantly after plasma exchange together with immunosuppression had been introduced.
14例年龄在20至59岁之间的患者（6名男性和8名女性）被诊断为抗肾小球基底膜肾小球肾炎。其中5例患者患有Goodpasture综合征，5例为快速进行性肾小球肾炎，1例为肾病综合征，1例为轻度肾小球肾炎。大多数患者的血压、蛋白尿和血尿并不严重。10例患者在终末期肾衰竭发生之前未能确诊。4例患者死于肺出血，3例患者的出血通过治疗得到控制，3例发生了无肺出血的肾衰竭，3例患者的肾功能得到改善或保持稳定。在采用血浆置换联合免疫抑制治疗后，预后有了显著改善。
