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Role of DNA repair in the mechanisms of cell resistance to alkylating agents and cisplatin.

作者信息

Calsou P, Salles B

机构信息

Laboratoire de Pharmacologie et Toxicologie Fondamentales, CNRS, Toulouse, France.

出版信息

Cancer Chemother Pharmacol. 1993;32(2):85-9. doi: 10.1007/BF00685607.

DOI:10.1007/BF00685607
PMID:8485812
Abstract
摘要

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1
Role of DNA repair in the mechanisms of cell resistance to alkylating agents and cisplatin.DNA修复在细胞对烷化剂和顺铂耐药机制中的作用。
Cancer Chemother Pharmacol. 1993;32(2):85-9. doi: 10.1007/BF00685607.
2
Alkylating and platinum-based agents.烷化剂和铂类药物。
Curr Opin Oncol. 1990 Dec;2(6):1109-14. doi: 10.1097/00001622-199012000-00014.
3
Modulation of antitumor alkylating agents (AA).抗肿瘤烷化剂（AA）的调节
Cancer Treat Res. 1991;57:261-95. doi: 10.1007/978-1-4615-3872-1_13.
4
Resistance to alkylating agents and cisplatin: insights from ovarian carcinoma model systems.对烷化剂和顺铂的耐药性：来自卵巢癌模型系统的见解。
Pharmacol Ther. 1990;48(1):19-27. doi: 10.1016/0163-7258(90)90015-t.
5
Alkylating agents, mechanisms of resistance: a review.烷化剂的耐药机制：综述
Prog Clin Biol Res. 1983;132C:247-55.
6
Mechanisms of resistance to alkylating agents.对烷化剂的耐药机制。
Cancer Treat Res. 1994;73:249-62. doi: 10.1007/978-1-4615-2632-2_12.
7
Gene expression analysis of tumor spheroids reveals a role for suppressed DNA mismatch repair in multicellular resistance to alkylating agents.肿瘤球体的基因表达分析揭示了DNA错配修复抑制在多细胞对烷化剂耐药中的作用。
Mol Cell Biol. 2004 Aug;24(15):6837-49. doi: 10.1128/MCB.24.15.6837-6849.2004.
8
c-MYC suppresses BIN1 to release poly(ADP-ribose) polymerase 1: a mechanism by which cancer cells acquire cisplatin resistance.c-MYC 抑制 BIN1 释放聚（ADP-核糖）聚合酶 1：癌细胞获得顺铂耐药性的一种机制。
Sci Signal. 2011 Mar 29;4(166):ra19. doi: 10.1126/scisignal.2001556.
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O6-alkylguanine-DNA alkyltransferase. A target for the modulation of drug resistance.O6-烷基鸟嘌呤-DNA烷基转移酶。耐药性调节的一个靶点。
Hematol Oncol Clin North Am. 1995 Apr;9(2):431-50.
10
Inhibition of DNA repair and the enhancement of cytotoxicity of alkylating agents.DNA修复的抑制及烷化剂细胞毒性的增强。
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Metformin enhances the radiosensitizing effect of cisplatin in non-small cell lung cancer cell lines with different cisplatin sensitivities.二甲双胍增强不同顺铂敏感性的非小细胞肺癌细胞系中顺铂的放射增敏作用。
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Cisplatin sensitizes cancer cells to ionizing radiation via inhibition of nonhomologous end joining.顺铂通过抑制非同源末端连接使癌细胞对电离辐射敏感。
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本文引用的文献

1
DNA cross-linking as an indicator of sensitivity and resistance of mouse L1210 leukemia to cis-diamminedichloroplatinum(II) and L-phenylalanine mustard.DNA交联作为小鼠L1210白血病对顺二氯二氨铂（II）和L-苯丙氨酸氮芥敏感性和抗性的指标。
Cancer Res. 1981 Feb;41(2):640-9.
2
DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells.亚硝基脲处理的人肿瘤细胞中的DNA交联与单加合物修复
Nature. 1980 Dec 25;288(5792):727-9. doi: 10.1038/288727a0.
3
Extracts of chronic lymphocytic leukemia lymphocytes have a high level of DNA repair activity fo O6-methylguanine.
顺铂使人类恶性胶质瘤细胞系对肿瘤坏死因子诱导的凋亡敏感。
J Neurooncol. 2001 Mar;52(1):23-36. doi: 10.1023/a:1010685110862.
4
Cisplatin resistant glioblastoma cells may have increased concentration of urokinase plasminogen activator and plasminogen activator inhibitor type 1.顺铂耐药的胶质母细胞瘤细胞可能具有更高浓度的尿激酶型纤溶酶原激活剂和1型纤溶酶原激活剂抑制剂。
J Neurooncol. 1999 Apr;42(2):95-102. doi: 10.1023/a:1006125629887.
5
In vitro circumvention of cisplatin resistance by the novel sterically hindered platinum complex AMD473.新型空间位阻铂配合物AMD473在体外对顺铂耐药性的规避
Br J Cancer. 1998;77(3):366-73. doi: 10.1038/bjc.1998.59.
6
Combination effects of poly(ADP-ribose) polymerase inhibitors and DNA-damaging agents in ovarian tumor cell lines--with special reference to cisplatin.聚（ADP - 核糖）聚合酶抑制剂与DNA损伤剂在卵巢肿瘤细胞系中的联合效应——特别提及顺铂
J Cancer Res Clin Oncol. 1996;122(11):665-70. doi: 10.1007/BF01209029.
7
Repair analysis of 4-hydroperoxycyclophosphamide-induced DNA interstrand crosslinking in the c-myc gene in 4-hydroperoxycyclophosphamide-sensitive and -resistant medulloblastoma cell lines.4-氢过氧环磷酰胺诱导的4-氢过氧环磷酰胺敏感和耐药髓母细胞瘤细胞系中c-myc基因DNA链间交联的修复分析
Cancer Chemother Pharmacol. 1996;37(3):242-46. doi: 10.1007/BF00688323.
8
Modulation of resistance to cisplatin by amphotericin B and aphidicolin in human larynx carcinoma cells.两性霉素B和阿非迪霉素对人喉癌细胞顺铂耐药性的调节作用
Cancer Chemother Pharmacol. 1995;35(4):327-33. doi: 10.1007/BF00689453.
9
Morphonuclear characterization of drug resistance by means of digital cell-image analysis: an in vitro assessment.通过数字细胞图像分析对耐药性进行形态核特征分析：一项体外评估
Cancer Chemother Pharmacol. 1995;37(1-2):179-86. doi: 10.1007/BF00685647.
慢性淋巴细胞白血病淋巴细胞提取物对O6-甲基鸟嘌呤具有高水平的DNA修复活性。
Proc Natl Acad Sci U S A. 1982 Aug;79(15):4786-90. doi: 10.1073/pnas.79.15.4786.
4
Susceptibility of Fanconi's anemia lymphoblasts to DNA-cross-linking and alkylating agents.范可尼贫血淋巴母细胞对DNA交联剂和烷化剂的敏感性。
Cancer Res. 1982 Oct;42(10):4000-6.
5
Defective removal of DNA cross-links in a repair-deficient mutant of Chinese hamster cells.中国仓鼠细胞修复缺陷型突变体中DNA交联去除缺陷
Cancer Res. 1982 Aug;42(8):3106-10.
6
Quenching of DNA:platinum(II) monoadducts as a possible mechanism of resistance to cis-diamminedichloroplatinum(II) in L1210 cells.DNA的淬灭：铂（II）单加合物作为L1210细胞对顺二氨二氯铂（II）耐药的一种可能机制
Cancer Res. 1983 Aug;43(8):3609-13.
7
Cross-linking of DNA induced by chloroethylnitrosourea is presented by O6-methylguanine-DNA methyltransferase.氯乙基亚硝脲诱导的DNA交联由O6-甲基鸟嘌呤-DNA甲基转移酶呈现。
Nucleic Acids Res. 1983 Nov 25;11(22):7743-58. doi: 10.1093/nar/11.22.7743.
8
Differential potentiation of alkylating and platinating agent cytotoxicity in human ovarian carcinoma cells by glutathione depletion.谷胱甘肽耗竭对人卵巢癌细胞中烷化剂和铂类药物细胞毒性的差异增强作用。
Cancer Res. 1985 Dec;45(12 Pt 1):6250-3.
9
Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion.丁硫氨酸亚砜胺介导的谷胱甘肽耗竭增强阿霉素、美法仑和顺铂对耐药及敏感人卵巢癌细胞系的细胞毒性。
Biochem Pharmacol. 1985 Jul 15;34(14):2583-6. doi: 10.1016/0006-2952(85)90551-9.
10
Formation and repair of DNA interstrand cross-links in relation to cytotoxicity and unscheduled DNA synthesis induced in control and mutant human cells treated with cis-diamminedichloroplatinum(II).顺二氨二氯铂（II）处理的对照及突变人类细胞中DNA链间交联的形成与修复及其与细胞毒性和DNA非预定合成的关系
Cancer Res. 1985 Sep;45(9):4178-84.