Basu A, Close C F, Jenkins D, Krentz A J, Nattrass M, Wright A D
General Hospital, Birmingham, UK.
Diabet Med. 1993 Apr;10(3):282-4. doi: 10.1111/j.1464-5491.1993.tb00060.x.
An overall hospital mortality rate of 3.9% was found in 929 episodes of diabetic ketoacidosis treated in single centre over a 21-year period. The mortality rate in the first half of the survey (4.4%) was not significantly different from that in the second half of the survey (3.4%). Six deaths in patients under 50 years of age occurred in the first half, but only one death under 50 years occurred in the second half of the survey. The number of deaths from a metabolic cause where no other illness was identified also fell from nine (43% of deaths) in the first half to five (33% of deaths) in the second half of the study (not significant). The remaining deaths were due to concurrent illness, mainly myocardial infarction and serious infections. Many of the residual deaths occurred in elderly patients with such medical illness in addition to the ketoacidosis. It may, therefore, prove difficult to reduce mortality further in diabetic ketoacidosis.
在21年的时间里，单中心治疗的929例糖尿病酮症酸中毒病例中，总体医院死亡率为3.9%。调查前半期的死亡率（4.4%）与后半期的死亡率（3.4%）无显著差异。前半期有6例50岁以下患者死亡，而后半期50岁以下患者仅1例死亡。在未发现其他疾病的情况下，代谢原因导致的死亡人数也从研究前半期的9例（占死亡人数的43%）降至后半期的5例（占死亡人数的33%）（无显著差异）。其余死亡是由并发疾病导致的，主要是心肌梗死和严重感染。许多剩余死亡发生在除酮症酸中毒外还患有此类疾病的老年患者中。因此，进一步降低糖尿病酮症酸中毒的死亡率可能会很困难。
