A method for testing the nonrandomness of chromosomal breakpoints.
作者信息
Tai J J, Hou C D, Wang-Wuu S, Wang C H, Leu S Y, Wuu K D
机构信息
Institute of Statistical Science, Academia Sinica, Taipei, Taiwan Republic of China.
出版信息
Cytogenet Cell Genet. 1993;63(3):147-50. doi: 10.1159/000133523.
PMID:8485989
Abstract
Testing the nonrandomness of breakage at a chromosome band is an essential step fo identifying a fragile site. In this paper, we propose a method derived by using the relationship between the binomial and F distributions for testing nonrandomness. The method is simple in calculation. It was applied to the detection of fragile sites for Chinese patients with colorectal carcinoma.
摘要
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